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Cascading MutS and MutL sliding clamps control DNA diffusion to activate mismatch repair

Author

Listed:
  • Jiaquan Liu

    (The Ohio State University Wexner Medical Center)

  • Jeungphill Hanne

    (The Ohio State University Wexner Medical Center)

  • Brooke M. Britton

    (The Ohio State University Wexner Medical Center)

  • Jared Bennett

    (The Ohio State University Wexner Medical Center)

  • Daehyung Kim

    (Pohang University of Science and Technology (POSTECH))

  • Jong-Bong Lee

    (Pohang University of Science and Technology (POSTECH)
    School of Interdisciplinary Bioscience and Bioengineering, POSTECH)

  • Richard Fishel

    (The Ohio State University Wexner Medical Center
    The Ohio State University)

Abstract

MutS and MutL—the highly conserved core proteins responsible for the repair of mismatched DNA—form sequential stable sliding clamps that together modulate one-dimensional diffusion along the DNA and, with MutH, facilitate the search for a distant excision initiation site.

Suggested Citation

  • Jiaquan Liu & Jeungphill Hanne & Brooke M. Britton & Jared Bennett & Daehyung Kim & Jong-Bong Lee & Richard Fishel, 2016. "Cascading MutS and MutL sliding clamps control DNA diffusion to activate mismatch repair," Nature, Nature, vol. 539(7630), pages 583-587, November.
    • Handle: RePEc:nat:nature:v:539:y:2016:i:7630:d:10.1038_nature20562
    DOI: 10.1038/nature20562
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    Citations

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    Cited by:

    1. Lina Wang & Siru Li & Kai Wang & Na Wang & Qiaoling Liu & Zhen Sun & Li Wang & Lulu Wang & Quentin Liu & Chengli Song & Caigang Liu & Qingkai Yang, 2022. "DNA mechanical flexibility controls DNA potential to activate cGAS-mediated immune surveillance," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    2. Xiao-Wen Yang & Xiao-Peng Han & Chong Han & James London & Richard Fishel & Jiaquan Liu, 2022. "MutS functions as a clamp loader by positioning MutL on the DNA during mismatch repair," Nature Communications, Nature, vol. 13(1), pages 1-17, December.

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