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Control of mitochondrial function and cell growth by the atypical cadherin Fat1

Author

Listed:
  • Longyue L. Cao

    (Wilf Family Cardiovascular Research Institute, Albert Einstein College of Medicine
    Albert Einstein College of Medicine)

  • Dario F. Riascos-Bernal

    (Wilf Family Cardiovascular Research Institute, Albert Einstein College of Medicine
    Albert Einstein College of Medicine)

  • Prameladevi Chinnasamy

    (Wilf Family Cardiovascular Research Institute, Albert Einstein College of Medicine
    Albert Einstein College of Medicine)

  • Charlene M. Dunaway

    (Wilf Family Cardiovascular Research Institute, Albert Einstein College of Medicine
    Albert Einstein College of Medicine)

  • Rong Hou

    (Wilf Family Cardiovascular Research Institute, Albert Einstein College of Medicine
    Albert Einstein College of Medicine
    †Present addresses: Department of Internal Medicine, Division of Infectious Diseases, Allergy, and Immunology, St. Louis University Hospital, St. Louis, Missouri 63104, USA (R.H.); Center for Autoimmune Genomics and Etiology, Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA (M.A.P).)

  • Mario A. Pujato

    (Albert Einstein College of Medicine
    †Present addresses: Department of Internal Medicine, Division of Infectious Diseases, Allergy, and Immunology, St. Louis University Hospital, St. Louis, Missouri 63104, USA (R.H.); Center for Autoimmune Genomics and Etiology, Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA (M.A.P).)

  • Brian P. O’Rourke

    (Albert Einstein College of Medicine)

  • Veronika Miskolci

    (Albert Einstein College of Medicine)

  • Liang Guo

    (CVPath Institute)

  • Louis Hodgson

    (Albert Einstein College of Medicine
    Gruss-Lipper Biophotonics Center, Albert Einstein College of Medicine)

  • Andras Fiser

    (Albert Einstein College of Medicine)

  • Nicholas E. S. Sibinga

    (Wilf Family Cardiovascular Research Institute, Albert Einstein College of Medicine
    Albert Einstein College of Medicine)

Abstract

Fragments of the atypical cadherin Fat1 accumulate in the mitochondria of vascular smooth muscle cells where they reduce respiration, leading to a regulated proliferative response to arterial injury.

Suggested Citation

  • Longyue L. Cao & Dario F. Riascos-Bernal & Prameladevi Chinnasamy & Charlene M. Dunaway & Rong Hou & Mario A. Pujato & Brian P. O’Rourke & Veronika Miskolci & Liang Guo & Louis Hodgson & Andras Fiser , 2016. "Control of mitochondrial function and cell growth by the atypical cadherin Fat1," Nature, Nature, vol. 539(7630), pages 575-578, November.
    • Handle: RePEc:nat:nature:v:539:y:2016:i:7630:d:10.1038_nature20170
    DOI: 10.1038/nature20170
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    Cited by:

    1. Elliot Medina & Yathreb Easa & Daniel K. Lester & Eric K. Lau & David Sprinzak & Vincent C. Luca, 2023. "Structure of the planar cell polarity cadherins Fat4 and Dachsous1," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    2. Rui Li & Jingchen Shao & Young-June Jin & Haruya Kawase & Yu Ting Ong & Kerstin Troidl & Qi Quan & Lei Wang & Remy Bonnavion & Astrid Wietelmann & Francoise Helmbacher & Michael Potente & Johannes Gra, 2023. "Endothelial FAT1 inhibits angiogenesis by controlling YAP/TAZ protein degradation via E3 ligase MIB2," Nature Communications, Nature, vol. 14(1), pages 1-17, December.

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