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An oxidative N-demethylase reveals PAS transition from ubiquitous sensor to enzyme

Author

Listed:
  • Mary Ortmayer

    (Manchester Institute of Biotechnology, School of Chemistry, 131 Princess Street, University of Manchester)

  • Pierre Lafite

    (Manchester Institute of Biotechnology, School of Chemistry, 131 Princess Street, University of Manchester
    †Present addresses : University of Orléans, CNRS, ICOA, UMR 7311, F-45067 Orléans, France (P.L.); German Federal Institute for Risk Assessment (BfR), Department of Chemicals and Product Safety, Max-Dohrn Str. 8-10, 10589 Berlin, Germany (T.T.).)

  • Binuraj R. K. Menon

    (Manchester Institute of Biotechnology, School of Chemistry, 131 Princess Street, University of Manchester)

  • Tewes Tralau

    (Manchester Institute of Biotechnology, School of Chemistry, 131 Princess Street, University of Manchester
    †Present addresses : University of Orléans, CNRS, ICOA, UMR 7311, F-45067 Orléans, France (P.L.); German Federal Institute for Risk Assessment (BfR), Department of Chemicals and Product Safety, Max-Dohrn Str. 8-10, 10589 Berlin, Germany (T.T.).)

  • Karl Fisher

    (Manchester Institute of Biotechnology, School of Chemistry, 131 Princess Street, University of Manchester)

  • Lukas Denkhaus

    (Manchester Institute of Biotechnology, School of Chemistry, 131 Princess Street, University of Manchester)

  • Nigel S. Scrutton

    (Manchester Institute of Biotechnology, School of Chemistry, 131 Princess Street, University of Manchester)

  • Stephen E. J. Rigby

    (Manchester Institute of Biotechnology, School of Chemistry, 131 Princess Street, University of Manchester)

  • Andrew W. Munro

    (Manchester Institute of Biotechnology, School of Chemistry, 131 Princess Street, University of Manchester)

  • Sam Hay

    (Manchester Institute of Biotechnology, School of Chemistry, 131 Princess Street, University of Manchester)

  • David Leys

    (Manchester Institute of Biotechnology, School of Chemistry, 131 Princess Street, University of Manchester)

Abstract

Characterization of the first Per-ARNT-Sim enzyme, a haem-dependent oxidative N-demethylase.

Suggested Citation

  • Mary Ortmayer & Pierre Lafite & Binuraj R. K. Menon & Tewes Tralau & Karl Fisher & Lukas Denkhaus & Nigel S. Scrutton & Stephen E. J. Rigby & Andrew W. Munro & Sam Hay & David Leys, 2016. "An oxidative N-demethylase reveals PAS transition from ubiquitous sensor to enzyme," Nature, Nature, vol. 539(7630), pages 593-597, November.
  • Handle: RePEc:nat:nature:v:539:y:2016:i:7630:d:10.1038_nature20159
    DOI: 10.1038/nature20159
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