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Ageing, neurodegeneration and brain rejuvenation

Author

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  • Tony Wyss-Coray

    (Stanford University School of Medicine
    Center for Tissue Regeneration, Repair and Restoration, VA Palo Alto Health Care System)

Abstract

Although systemic diseases take the biggest toll on human health and well-being, increasingly, a failing brain is the arbiter of a death preceded by a gradual loss of the essence of being. Ageing, which is fundamental to neurodegeneration and dementia, affects every organ in the body and seems to be encoded partly in a blood-based signature. Indeed, factors in the circulation have been shown to modulate ageing and to rejuvenate numerous organs, including the brain. The discovery of such factors, the identification of their origins and a deeper understanding of their functions is ushering in a new era in ageing and dementia research.

Suggested Citation

  • Tony Wyss-Coray, 2016. "Ageing, neurodegeneration and brain rejuvenation," Nature, Nature, vol. 539(7628), pages 180-186, November.
    • Handle: RePEc:nat:nature:v:539:y:2016:i:7628:d:10.1038_nature20411
    DOI: 10.1038/nature20411
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    Cited by:

    1. Doyeon Lee & Seungwook Kim & Keunhwan Kim, 2020. "International R&D Collaboration for a Global Aging Society: Focusing on Aging-Related National-Funded Projects," IJERPH, MDPI, vol. 17(22), pages 1-22, November.
    2. Simone Bido & Sharon Muggeo & Luca Massimino & Matteo Jacopo Marzi & Serena Gea Giannelli & Elena Melacini & Melania Nannoni & Diana Gambarè & Edoardo Bellini & Gabriele Ordazzo & Greta Rossi & Camill, 2021. "Microglia-specific overexpression of α-synuclein leads to severe dopaminergic neurodegeneration by phagocytic exhaustion and oxidative toxicity," Nature Communications, Nature, vol. 12(1), pages 1-15, December.
    3. Byung Jo Choi & Min Hee Park & Kang Ho Park & Wan Hui Han & Hee Ji Yoon & Hye Yoon Jung & Ju Yeon Hong & Md Riad Chowdhury & Kyung Yeol Kim & Jihoon Lee & Im-Sook Song & Minyeong Pang & Min-Koo Choi &, 2023. "Immunotherapy targeting plasma ASM is protective in a mouse model of Alzheimer’s disease," Nature Communications, Nature, vol. 14(1), pages 1-17, December.

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