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Targeting renal cell carcinoma with a HIF-2 antagonist

Author

Listed:
  • Wenfang Chen

    (Kidney Cancer Program, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center
    University of Texas Southwestern Medical Center
    the First Affiliated Hospital of Sun Yat-sen University)

  • Haley Hill

    (Kidney Cancer Program, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center
    University of Texas Southwestern Medical Center)

  • Alana Christie

    (Kidney Cancer Program, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center)

  • Min Soo Kim

    (Kidney Cancer Program, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center
    University of Texas Southwestern Medical Center)

  • Eboni Holloman

    (Kidney Cancer Program, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center
    University of Texas Southwestern Medical Center)

  • Andrea Pavia-Jimenez

    (Kidney Cancer Program, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center
    University of Texas Southwestern Medical Center)

  • Farrah Homayoun

    (Kidney Cancer Program, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center
    University of Texas Southwestern Medical Center)

  • Yuanqing Ma

    (Kidney Cancer Program, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center
    University of Texas Southwestern Medical Center)

  • Nirav Patel

    (Kidney Cancer Program, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center
    University of Texas Southwestern Medical Center)

  • Paul Yell

    (Parkland Health and Hospital System)

  • Guiyang Hao

    (University of Texas Southwestern Medical Center)

  • Qurratulain Yousuf

    (Kidney Cancer Program, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center
    University of Texas Southwestern Medical Center)

  • Allison Joyce

    (Kidney Cancer Program, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center
    University of Texas Southwestern Medical Center)

  • Ivan Pedrosa

    (Kidney Cancer Program, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center
    University of Texas Southwestern Medical Center)

  • Heather Geiger

    (New York Genome Center)

  • He Zhang

    (Kidney Cancer Program, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center
    University of Texas Southwestern Medical Center)

  • Jenny Chang

    (Kidney Cancer Program, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center)

  • Kevin H. Gardner

    (Structural Biology Initiative, CUNY Advanced Science Research Center
    City College of New York
    Biochemistry, Chemistry and Biology Ph.D. Programs, Graduate Center, City University of New York)

  • Richard K. Bruick

    (Kidney Cancer Program, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center
    University of Texas Southwestern Medical Center)

  • Catherine Reeves

    (New York Genome Center)

  • Tae Hyun Hwang

    (Kidney Cancer Program, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center
    University of Texas Southwestern Medical Center)

  • Kevin Courtney

    (Kidney Cancer Program, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center
    University of Texas Southwestern Medical Center)

  • Eugene Frenkel

    (Kidney Cancer Program, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center
    University of Texas Southwestern Medical Center)

  • Xiankai Sun

    (Kidney Cancer Program, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center
    University of Texas Southwestern Medical Center)

  • Naseem Zojwalla

    (Peloton Therapeutics Inc.)

  • Tai Wong

    (Peloton Therapeutics Inc.)

  • James P. Rizzi

    (Peloton Therapeutics Inc.)

  • Eli M. Wallace

    (Peloton Therapeutics Inc.)

  • John A. Josey

    (Peloton Therapeutics Inc.)

  • Yang Xie

    (Kidney Cancer Program, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center
    University of Texas Southwestern Medical Center)

  • Xian-Jin Xie

    (Kidney Cancer Program, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center
    University of Texas Southwestern Medical Center)

  • Payal Kapur

    (Kidney Cancer Program, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center
    University of Texas Southwestern Medical Center)

  • Renée M. McKay

    (Kidney Cancer Program, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center
    University of Texas Southwestern Medical Center)

  • James Brugarolas

    (Kidney Cancer Program, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center
    University of Texas Southwestern Medical Center)

Abstract

The HIF-2 antagonist PT2399 is tested in mice bearing tumourgrafts derived from human renal cell cancers to demonstrate its efficacy, identify markers of sensitivity and characterize its effects.

Suggested Citation

  • Wenfang Chen & Haley Hill & Alana Christie & Min Soo Kim & Eboni Holloman & Andrea Pavia-Jimenez & Farrah Homayoun & Yuanqing Ma & Nirav Patel & Paul Yell & Guiyang Hao & Qurratulain Yousuf & Allison , 2016. "Targeting renal cell carcinoma with a HIF-2 antagonist," Nature, Nature, vol. 539(7627), pages 112-117, November.
    • Handle: RePEc:nat:nature:v:539:y:2016:i:7627:d:10.1038_nature19796
    DOI: 10.1038/nature19796
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    Cited by:

    1. Jin Zhou & Austin Hepperla & Jeremy M. Simon & Kangsan Kim & Qing Hu & Chuanhai Zhang & Lei Dong & Lianxin Hu & Cheng Zhang & Chengheng Liao & Alice Fang & Yayoi Adachi & Haoyong Fu & Tao Wang & Qian , 2025. "SWI/SNF ATPase silenced HLF potentiates lung metastasis in solid cancers," Nature Communications, Nature, vol. 16(1), pages 1-19, December.
    2. Shuyan Dai & Lingzhi Qu & Jun Li & Ye Zhang & Longying Jiang & Hudie Wei & Ming Guo & Xiaojuan Chen & Yongheng Chen, 2022. "Structural insight into the ligand binding mechanism of aryl hydrocarbon receptor," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    3. Rebecca M. Mello & Diego Gomez Ceballos & Colby R. Sandate & Sicong Wang & Celine Jouffe & Daniel Agudelo & Nina Henriette Uhlenhaut & Nicolas H. Thomä & M. Celeste Simon & Katja A. Lamia, 2025. "BMAL1 and ARNT enable circadian HIF2α responses in clear cell renal cell carcinoma," Nature Communications, Nature, vol. 16(1), pages 1-17, December.

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