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Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne

Author

Listed:
  • Tycho E. T. Mevissen

    (Medical Research Council Laboratory of Molecular Biology)

  • Yogesh Kulathu

    (Medical Research Council Laboratory of Molecular Biology
    †Present addresses: Medical Research Council Protein Phosphorylation and Ubiquitylation Unit, Dow Street, Dundee, DD1 5EH, UK (Y.K.); Chemical Immunology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands (M.P.C.M., P.P.G., H.O.); Department of Biochemistry and Microbiology, University of Victoria, 270 Petch Hall, Victoria BC, Canada (J.E.B.); Buchmann Institute for Molecular Life Sciences, Goethe University, 60438 Frankfurt am Main, Germany (M.A.); UbiQ Bio BV, Science Park 408, 1098 XH, Amsterdam, The Netherlands (F.E.O.).)

  • Monique P.C. Mulder

    (Netherlands Cancer Institute, Plesmanlaan 121
    †Present addresses: Medical Research Council Protein Phosphorylation and Ubiquitylation Unit, Dow Street, Dundee, DD1 5EH, UK (Y.K.); Chemical Immunology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands (M.P.C.M., P.P.G., H.O.); Department of Biochemistry and Microbiology, University of Victoria, 270 Petch Hall, Victoria BC, Canada (J.E.B.); Buchmann Institute for Molecular Life Sciences, Goethe University, 60438 Frankfurt am Main, Germany (M.A.); UbiQ Bio BV, Science Park 408, 1098 XH, Amsterdam, The Netherlands (F.E.O.).)

  • Paul P. Geurink

    (Netherlands Cancer Institute, Plesmanlaan 121
    †Present addresses: Medical Research Council Protein Phosphorylation and Ubiquitylation Unit, Dow Street, Dundee, DD1 5EH, UK (Y.K.); Chemical Immunology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands (M.P.C.M., P.P.G., H.O.); Department of Biochemistry and Microbiology, University of Victoria, 270 Petch Hall, Victoria BC, Canada (J.E.B.); Buchmann Institute for Molecular Life Sciences, Goethe University, 60438 Frankfurt am Main, Germany (M.A.); UbiQ Bio BV, Science Park 408, 1098 XH, Amsterdam, The Netherlands (F.E.O.).)

  • Sarah L. Maslen

    (Medical Research Council Laboratory of Molecular Biology)

  • Malte Gersch

    (Medical Research Council Laboratory of Molecular Biology)

  • Paul R. Elliott

    (Medical Research Council Laboratory of Molecular Biology)

  • John E. Burke

    (Medical Research Council Laboratory of Molecular Biology
    †Present addresses: Medical Research Council Protein Phosphorylation and Ubiquitylation Unit, Dow Street, Dundee, DD1 5EH, UK (Y.K.); Chemical Immunology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands (M.P.C.M., P.P.G., H.O.); Department of Biochemistry and Microbiology, University of Victoria, 270 Petch Hall, Victoria BC, Canada (J.E.B.); Buchmann Institute for Molecular Life Sciences, Goethe University, 60438 Frankfurt am Main, Germany (M.A.); UbiQ Bio BV, Science Park 408, 1098 XH, Amsterdam, The Netherlands (F.E.O.).)

  • Bianca D. M. van Tol

    (Netherlands Cancer Institute, Plesmanlaan 121)

  • Masato Akutsu

    (Medical Research Council Laboratory of Molecular Biology
    †Present addresses: Medical Research Council Protein Phosphorylation and Ubiquitylation Unit, Dow Street, Dundee, DD1 5EH, UK (Y.K.); Chemical Immunology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands (M.P.C.M., P.P.G., H.O.); Department of Biochemistry and Microbiology, University of Victoria, 270 Petch Hall, Victoria BC, Canada (J.E.B.); Buchmann Institute for Molecular Life Sciences, Goethe University, 60438 Frankfurt am Main, Germany (M.A.); UbiQ Bio BV, Science Park 408, 1098 XH, Amsterdam, The Netherlands (F.E.O.).)

  • Farid El Oualid

    (Netherlands Cancer Institute, Plesmanlaan 121
    †Present addresses: Medical Research Council Protein Phosphorylation and Ubiquitylation Unit, Dow Street, Dundee, DD1 5EH, UK (Y.K.); Chemical Immunology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands (M.P.C.M., P.P.G., H.O.); Department of Biochemistry and Microbiology, University of Victoria, 270 Petch Hall, Victoria BC, Canada (J.E.B.); Buchmann Institute for Molecular Life Sciences, Goethe University, 60438 Frankfurt am Main, Germany (M.A.); UbiQ Bio BV, Science Park 408, 1098 XH, Amsterdam, The Netherlands (F.E.O.).)

  • Masato Kawasaki

    (Structural Biology Research Center, Photon Factory, Institute of Materials Structure Science, High Energy Accelerator Research Organization (KEK))

  • Stefan M.V. Freund

    (Medical Research Council Laboratory of Molecular Biology)

  • Huib Ovaa

    (Netherlands Cancer Institute, Plesmanlaan 121
    †Present addresses: Medical Research Council Protein Phosphorylation and Ubiquitylation Unit, Dow Street, Dundee, DD1 5EH, UK (Y.K.); Chemical Immunology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands (M.P.C.M., P.P.G., H.O.); Department of Biochemistry and Microbiology, University of Victoria, 270 Petch Hall, Victoria BC, Canada (J.E.B.); Buchmann Institute for Molecular Life Sciences, Goethe University, 60438 Frankfurt am Main, Germany (M.A.); UbiQ Bio BV, Science Park 408, 1098 XH, Amsterdam, The Netherlands (F.E.O.).)

  • David Komander

    (Medical Research Council Laboratory of Molecular Biology)

Abstract

The structures of the deubiquitinating enzyme Cezanne alone or in complex with its substrate or product are solved, showing how Cezanne specifically targets Lys11-linked polyubiquitin.

Suggested Citation

  • Tycho E. T. Mevissen & Yogesh Kulathu & Monique P.C. Mulder & Paul P. Geurink & Sarah L. Maslen & Malte Gersch & Paul R. Elliott & John E. Burke & Bianca D. M. van Tol & Masato Akutsu & Farid El Ouali, 2016. "Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne," Nature, Nature, vol. 538(7625), pages 402-405, October.
    • Handle: RePEc:nat:nature:v:538:y:2016:i:7625:d:10.1038_nature19836
    DOI: 10.1038/nature19836
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