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A cholinergic basal forebrain feeding circuit modulates appetite suppression

Author

Listed:
  • Alexander M. Herman

    (Program in Developmental Biology, Baylor College of Medicine)

  • Joshua Ortiz-Guzman

    (Program in Developmental Biology, Baylor College of Medicine)

  • Mikhail Kochukov

    (Baylor College of Medicine)

  • Isabella Herman

    (Program in Developmental Biology, Baylor College of Medicine
    Medical Scientist Training Program, Baylor College of Medicine)

  • Kathleen B. Quast

    (Baylor College of Medicine)

  • Jay M. Patel

    (Medical Scientist Training Program, Baylor College of Medicine
    Baylor College of Medicine)

  • Burak Tepe

    (Program in Developmental Biology, Baylor College of Medicine)

  • Jeffrey C. Carlson

    (Program in Developmental Biology, Baylor College of Medicine)

  • Kevin Ung

    (Program in Developmental Biology, Baylor College of Medicine)

  • Jennifer Selever

    (Baylor College of Medicine
    Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital)

  • Qingchun Tong

    (Institute of Molecular Medicine, University of Texas Health Science Center)

  • Benjamin R. Arenkiel

    (Program in Developmental Biology, Baylor College of Medicine
    Baylor College of Medicine
    Baylor College of Medicine
    Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital)

Abstract

A mouse study reveals that acetylcholine signalling networks have a role in the regulation of body weight homeostasis, with increased activity of cholinergic neurons decreasing food consumption through downstream hypothalamic targets.

Suggested Citation

  • Alexander M. Herman & Joshua Ortiz-Guzman & Mikhail Kochukov & Isabella Herman & Kathleen B. Quast & Jay M. Patel & Burak Tepe & Jeffrey C. Carlson & Kevin Ung & Jennifer Selever & Qingchun Tong & Ben, 2016. "A cholinergic basal forebrain feeding circuit modulates appetite suppression," Nature, Nature, vol. 538(7624), pages 253-256, October.
    • Handle: RePEc:nat:nature:v:538:y:2016:i:7624:d:10.1038_nature19789
    DOI: 10.1038/nature19789
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    Cited by:

    1. Laia Guardia-Escote & Jordi Blanco & Pia Basaure & Judit Biosca-Brull & Rikst Nynke Verkaik-Schakel & Maria Cabré & Fiona Peris-Sampedro & Cristian Pérez-Fernández & Fernando Sánchez-Santed & Torsten , 2020. "Sex and Exposure to Postnatal Chlorpyrifos Influence the Epigenetics of Feeding-Related Genes in a Transgenic APOE Mouse Model: Long-Term Implications on Body Weight after a High-Fat Diet," IJERPH, MDPI, vol. 18(1), pages 1-17, December.

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