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The prion protein is an agonistic ligand of the G protein-coupled receptor Adgrg6

Author

Listed:
  • Alexander Küffer

    (Institute of Neuropathology, University of Zurich)

  • Asvin K. K. Lakkaraju

    (Institute of Neuropathology, University of Zurich)

  • Amit Mogha

    (Washington University School of Medicine)

  • Sarah C. Petersen

    (Washington University School of Medicine)

  • Kristina Airich

    (Institute of Neuropathology, University of Zurich)

  • Cédric Doucerain

    (Institute of Neuropathology, University of Zurich)

  • Rajlakshmi Marpakwar

    (Institute of Neuropathology, University of Zurich)

  • Pamela Bakirci

    (Institute of Neuropathology, University of Zurich)

  • Assunta Senatore

    (Institute of Neuropathology, University of Zurich)

  • Arnaud Monnard

    (Institute of Neuropathology, University of Zurich)

  • Carmen Schiavi

    (Institute of Neuropathology, University of Zurich)

  • Mario Nuvolone

    (Institute of Neuropathology, University of Zurich)

  • Bianka Grosshans

    (Novartis Institutes for Biomedical Research)

  • Simone Hornemann

    (Institute of Neuropathology, University of Zurich)

  • Frederic Bassilana

    (Novartis Institutes for Biomedical Research)

  • Kelly R. Monk

    (Washington University School of Medicine)

  • Adriano Aguzzi

    (Institute of Neuropathology, University of Zurich)

Abstract

The cellular prion protein PrPC promotes peripheral myelin homeostasis by acting on a G protein-coupled receptor to increase levels of cyclic AMP in Schwann cells.

Suggested Citation

  • Alexander Küffer & Asvin K. K. Lakkaraju & Amit Mogha & Sarah C. Petersen & Kristina Airich & Cédric Doucerain & Rajlakshmi Marpakwar & Pamela Bakirci & Assunta Senatore & Arnaud Monnard & Carmen Schi, 2016. "The prion protein is an agonistic ligand of the G protein-coupled receptor Adgrg6," Nature, Nature, vol. 536(7617), pages 464-468, August.
    • Handle: RePEc:nat:nature:v:536:y:2016:i:7617:d:10.1038_nature19312
    DOI: 10.1038/nature19312
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