IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v535y2016i7613d10.1038_nature18589.html
   My bibliography  Save this article

Structural organization of the inactive X chromosome in the mouse

Author

Listed:
  • Luca Giorgetti

    (Institut Curie, PSL Research University, CNRS UMR3215, INSERM U934
    †Present address: Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH-4058 Basel, Switzerland.)

  • Bryan R. Lajoie

    (Program in Systems Biology, University of Massachusetts Medical School)

  • Ava C. Carter

    (Center for Personal Dynamic Regulomes and Program in Epithelial Biology, Stanford University School of Medicine)

  • Mikael Attia

    (Institut Curie, PSL Research University, CNRS UMR3215, INSERM U934)

  • Ye Zhan

    (Program in Systems Biology, University of Massachusetts Medical School)

  • Jin Xu

    (Center for Personal Dynamic Regulomes and Program in Epithelial Biology, Stanford University School of Medicine)

  • Chong Jian Chen

    (Institut Curie, PSL Research University, CNRS UMR3215, INSERM U934)

  • Noam Kaplan

    (Program in Systems Biology, University of Massachusetts Medical School)

  • Howard Y. Chang

    (Center for Personal Dynamic Regulomes and Program in Epithelial Biology, Stanford University School of Medicine)

  • Edith Heard

    (Institut Curie, PSL Research University, CNRS UMR3215, INSERM U934
    Collège de France)

  • Job Dekker

    (Program in Systems Biology, University of Massachusetts Medical School
    Howard Hughes Medical Institute, University of Massachusetts Medical School)

Abstract

An in-depth analysis of the structure, chromatin accessibility and expression status of the mouse inactive X (Xi) chromosome provides insights into the regulation of Xi chromosome structure, its dependence on the macrosatellite DXZ4 region, the Xist non-coding RNA, as well as the basis for topologically associating domain (TAD) formation on the Xi.

Suggested Citation

  • Luca Giorgetti & Bryan R. Lajoie & Ava C. Carter & Mikael Attia & Ye Zhan & Jin Xu & Chong Jian Chen & Noam Kaplan & Howard Y. Chang & Edith Heard & Job Dekker, 2016. "Structural organization of the inactive X chromosome in the mouse," Nature, Nature, vol. 535(7613), pages 575-579, July.
    • Handle: RePEc:nat:nature:v:535:y:2016:i:7613:d:10.1038_nature18589
    DOI: 10.1038/nature18589
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature18589
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature18589?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Antonio Lentini & Huaitao Cheng & J. C. Noble & Natali Papanicolaou & Christos Coucoravas & Nathanael Andrews & Qiaolin Deng & Martin Enge & Björn Reinius, 2022. "Elastic dosage compensation by X-chromosome upregulation," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    2. Andrew Keniry & Natasha Jansz & Linden J. Gearing & Iromi Wanigasuriya & Joseph Chen & Christian M. Nefzger & Peter F. Hickey & Quentin Gouil & Joy Liu & Kelsey A. Breslin & Megan Iminitoff & Tamara B, 2022. "BAF complex-mediated chromatin relaxation is required for establishment of X chromosome inactivation," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    3. Sandhya Chandrasekaran & Sergio Espeso-Gil & Yong-Hwee Eddie Loh & Behnam Javidfar & Bibi Kassim & Yueyan Zhu & Yuan Zhang & Yuhao Dong & Lucy K. Bicks & Haixin Li & Prashanth Rajarajan & Cyril J. Pet, 2021. "Neuron-specific chromosomal megadomain organization is adaptive to recent retrotransposon expansions," Nature Communications, Nature, vol. 12(1), pages 1-16, December.
    4. Mayank N. K. Choudhary & Kara Quaid & Xiaoyun Xing & Heather Schmidt & Ting Wang, 2023. "Widespread contribution of transposable elements to the rewiring of mammalian 3D genomes," Nature Communications, Nature, vol. 14(1), pages 1-12, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:535:y:2016:i:7613:d:10.1038_nature18589. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.