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Accounting for reciprocal host–microbiome interactions in experimental science

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  • Thaddeus S. Stappenbeck

    (Washington University School of Medicine, Campus Box 8118)

  • Herbert W. Virgin

    (Washington University School of Medicine, Campus Box 8118)

Abstract

Mammals are defined by their metagenome, a combination of host and microbiome genes. This knowledge presents opportunities to further basic biology with translation to human diseases. However, the now-documented influence of the metagenome on experimental results and the reproducibility of in vivo mammalian models present new challenges. Here we provide the scientific basis for calling on all investigators, editors and funding agencies to embrace changes that will enhance reproducible and interpretable experiments by accounting for metagenomic effects. Implementation of new reporting and experimental design principles will improve experimental work, speed discovery and translation, and properly use substantial investments in biomedical research.

Suggested Citation

  • Thaddeus S. Stappenbeck & Herbert W. Virgin, 2016. "Accounting for reciprocal host–microbiome interactions in experimental science," Nature, Nature, vol. 534(7606), pages 191-199, June.
    • Handle: RePEc:nat:nature:v:534:y:2016:i:7606:d:10.1038_nature18285
    DOI: 10.1038/nature18285
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    Cited by:

    1. Marion Darnaud & Filipe Vadder & Pascaline Bogeat & Lilia Boucinha & Anne-Laure Bulteau & Andrei Bunescu & Céline Couturier & Ana Delgado & Hélène Dugua & Céline Elie & Alban Mathieu & Tereza Novotná , 2021. "A standardized gnotobiotic mouse model harboring a minimal 15-member mouse gut microbiota recapitulates SOPF/SPF phenotypes," Nature Communications, Nature, vol. 12(1), pages 1-21, December.

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