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Overcoming mTOR resistance mutations with a new-generation mTOR inhibitor

Author

Listed:
  • Vanessa S. Rodrik-Outmezguine

    (Program in Molecular Pharmacology, Memorial Sloan-Kettering Cancer Center)

  • Masanori Okaniwa

    (University of California San Francisco)

  • Zhan Yao

    (Program in Molecular Pharmacology, Memorial Sloan-Kettering Cancer Center)

  • Chris J. Novotny

    (University of California San Francisco)

  • Claire McWhirter

    (AstraZeneca, Alderley Park)

  • Arpitha Banaji

    (Program in Molecular Pharmacology, Memorial Sloan-Kettering Cancer Center)

  • Helen Won

    (Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center)

  • Wai Wong

    (Anti-Tumor Assessment Core, Memorial Sloan Kettering Cancer Center)

  • Mike Berger

    (Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center)

  • Elisa de Stanchina

    (Anti-Tumor Assessment Core, Memorial Sloan Kettering Cancer Center)

  • Derek G. Barratt

    (AstraZeneca, Alderley Park)

  • Sabina Cosulich

    (AstraZeneca, Alderley Park)

  • Teresa Klinowska

    (AstraZeneca, Alderley Park)

  • Neal Rosen

    (Program in Molecular Pharmacology, Memorial Sloan-Kettering Cancer Center
    Memorial Sloan Kettering Cancer Center)

  • Kevan M. Shokat

    (University of California San Francisco
    University of California Berkeley)

Abstract

Inhibitors of the mTOR kinase are in clinical trials for the treatment of cancer; here, mutations in mTOR that can lead to drug resistance are investigated and the results are used to design a new class of mTOR inhibitors that can overcome this resistance.

Suggested Citation

  • Vanessa S. Rodrik-Outmezguine & Masanori Okaniwa & Zhan Yao & Chris J. Novotny & Claire McWhirter & Arpitha Banaji & Helen Won & Wai Wong & Mike Berger & Elisa de Stanchina & Derek G. Barratt & Sabina, 2016. "Overcoming mTOR resistance mutations with a new-generation mTOR inhibitor," Nature, Nature, vol. 534(7606), pages 272-276, June.
    • Handle: RePEc:nat:nature:v:534:y:2016:i:7606:d:10.1038_nature17963
    DOI: 10.1038/nature17963
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    Cited by:

    1. Sébastien Levesque & Diana Mayorga & Jean-Philippe Fiset & Claudia Goupil & Alexis Duringer & Andréanne Loiselle & Eva Bouchard & Daniel Agudelo & Yannick Doyon, 2022. "Marker-free co-selection for successive rounds of prime editing in human cells," Nature Communications, Nature, vol. 13(1), pages 1-14, December.

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