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Pitx2 promotes heart repair by activating the antioxidant response after cardiac injury

Author

Listed:
  • Ge Tao

    (Baylor College of Medicine)

  • Peter C. Kahr

    (Baylor College of Medicine)

  • Yuka Morikawa

    (Texas Heart Institute)

  • Min Zhang

    (Baylor College of Medicine)

  • Mahdis Rahmani

    (Texas Heart Institute)

  • Todd R. Heallen

    (Texas Heart Institute)

  • Lele Li

    (Baylor College of Medicine)

  • Zhao Sun

    (The University of Iowa)

  • Eric N. Olson

    (University of Texas Southwestern Medical Center)

  • Brad A. Amendt

    (The University of Iowa)

  • James F. Martin

    (Baylor College of Medicine
    Texas Heart Institute
    Program in Developmental Biology, Baylor College of Medicine
    Cardiovascular Research Institute, Baylor College of Medicine)

Abstract

The transcription factor Pitx2 is upregulated in injured neonatal and Hippo-deficient mouse hearts, where it interacts with the Hippo effector protein Yap to activate reactive oxygen species scavengers, thus preventing the heart from oxidative damage.

Suggested Citation

  • Ge Tao & Peter C. Kahr & Yuka Morikawa & Min Zhang & Mahdis Rahmani & Todd R. Heallen & Lele Li & Zhao Sun & Eric N. Olson & Brad A. Amendt & James F. Martin, 2016. "Pitx2 promotes heart repair by activating the antioxidant response after cardiac injury," Nature, Nature, vol. 534(7605), pages 119-123, June.
    • Handle: RePEc:nat:nature:v:534:y:2016:i:7605:d:10.1038_nature17959
    DOI: 10.1038/nature17959
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    Cited by:

    1. Yu Chen & Shuai Liu & Yunsong Liang & Yutong He & Qian Li & Jiamian Zhan & Honghao Hou & Xiaozhong Qiu, 2024. "Single dose of intravenous miR199a-5p delivery targeting ischemic heart for long-term repair of myocardial infarction," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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