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Feedback modulation of cholesterol metabolism by the lipid-responsive non-coding RNA LeXis

Author

Listed:
  • Tamer Sallam

    (Howard Hughes Medical Institute, University of California
    University of California)

  • Marius C. Jones

    (Howard Hughes Medical Institute, University of California)

  • Thomas Gilliland

    (Howard Hughes Medical Institute, University of California)

  • Li Zhang

    (Howard Hughes Medical Institute, University of California)

  • Xiaohui Wu

    (Howard Hughes Medical Institute, University of California
    University of California)

  • Ascia Eskin

    (Departement of Human Genetics, University of California)

  • Jaspreet Sandhu

    (Howard Hughes Medical Institute, University of California)

  • David Casero

    (Howard Hughes Medical Institute, University of California)

  • Thomas Q. de Aguiar Vallim

    (University of California)

  • Cynthia Hong

    (Howard Hughes Medical Institute, University of California)

  • Melanie Katz

    (Ionis Pharmaceuticals)

  • Richard Lee

    (Ionis Pharmaceuticals)

  • Julian Whitelegge

    (Pasarow Mass Spectrometry Laboratory, NPI-Semel Institute, University of California)

  • Peter Tontonoz

    (Howard Hughes Medical Institute, University of California)

Abstract

The activation of lipid X receptors (LXRs) in mouse liver not only promotes cholesterol efflux but also inhibits cholesterol synthesis simultaneously; this is mediated by the lipid-responsive long non-coding RNA LeXis, which is induced by a Western diet and orchestrates crosstalk between LXRs and the cholesterol biosynthetic pathway.

Suggested Citation

  • Tamer Sallam & Marius C. Jones & Thomas Gilliland & Li Zhang & Xiaohui Wu & Ascia Eskin & Jaspreet Sandhu & David Casero & Thomas Q. de Aguiar Vallim & Cynthia Hong & Melanie Katz & Richard Lee & Juli, 2016. "Feedback modulation of cholesterol metabolism by the lipid-responsive non-coding RNA LeXis," Nature, Nature, vol. 534(7605), pages 124-128, June.
    • Handle: RePEc:nat:nature:v:534:y:2016:i:7605:d:10.1038_nature17674
    DOI: 10.1038/nature17674
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