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An obligatory role for neurotensin in high-fat-diet-induced obesity

Author

Listed:
  • Jing Li

    (University of Kentucky
    Markey Cancer Center, University of Kentucky)

  • Jun Song

    (University of Kentucky
    Markey Cancer Center, University of Kentucky)

  • Yekaterina Y. Zaytseva

    (Markey Cancer Center, University of Kentucky
    University of Kentucky)

  • Yajuan Liu

    (Markey Cancer Center, University of Kentucky)

  • Piotr Rychahou

    (University of Kentucky
    Markey Cancer Center, University of Kentucky)

  • Kai Jiang

    (Markey Cancer Center, University of Kentucky)

  • Marlene E. Starr

    (University of Kentucky)

  • Ji Tae Kim

    (University of Kentucky
    Markey Cancer Center, University of Kentucky)

  • Jennifer W. Harris

    (University of Kentucky
    Markey Cancer Center, University of Kentucky)

  • Frederique B. Yiannikouris

    (University of Kentucky)

  • Wendy S. Katz

    (University of Kentucky)

  • Peter M. Nilsson

    (Lund University
    Skåne University Hospital)

  • Marju Orho-Melander

    (Lund University)

  • Jing Chen

    (University of Kentucky
    Center for Structural Biology, University of Kentucky)

  • Haining Zhu

    (University of Kentucky
    Center for Structural Biology, University of Kentucky)

  • Timothy Fahrenholz

    (Markey Cancer Center, University of Kentucky
    University of Kentucky
    Center for Environmental and Systems Biochemistry, University of Kentucky)

  • Richard M. Higashi

    (Markey Cancer Center, University of Kentucky
    University of Kentucky
    Center for Environmental and Systems Biochemistry, University of Kentucky)

  • Tianyan Gao

    (Markey Cancer Center, University of Kentucky
    University of Kentucky)

  • Andrew J. Morris

    (Gill Heart Institute, University of Kentucky and Lexington Veterans Affairs Medical Center)

  • Lisa A. Cassis

    (University of Kentucky)

  • Teresa W. -M. Fan

    (Markey Cancer Center, University of Kentucky
    University of Kentucky
    Center for Environmental and Systems Biochemistry, University of Kentucky)

  • Heidi L. Weiss

    (Markey Cancer Center, University of Kentucky
    University of Kentucky)

  • Paul R. Dobner

    (University of Massachusetts Medical School)

  • Olle Melander

    (Lund University
    Skåne University Hospital)

  • Jianhang Jia

    (Markey Cancer Center, University of Kentucky
    University of Kentucky)

  • B. Mark Evers

    (University of Kentucky
    Markey Cancer Center, University of Kentucky)

Abstract

Neurotensin, a peptide expressed in the enteroendocrine cells of the small intestine that is released upon fat ingestion, is shown to increase fatty acid absorption, with neurotensin-deficient mice being protected from obesity induced by a high-fat diet.

Suggested Citation

  • Jing Li & Jun Song & Yekaterina Y. Zaytseva & Yajuan Liu & Piotr Rychahou & Kai Jiang & Marlene E. Starr & Ji Tae Kim & Jennifer W. Harris & Frederique B. Yiannikouris & Wendy S. Katz & Peter M. Nilss, 2016. "An obligatory role for neurotensin in high-fat-diet-induced obesity," Nature, Nature, vol. 533(7603), pages 411-415, May.
    • Handle: RePEc:nat:nature:v:533:y:2016:i:7603:d:10.1038_nature17662
    DOI: 10.1038/nature17662
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    Cited by:

    1. Maximilian Tremmel & Ulf-G. Gerdtham & Peter M. Nilsson & Sanjib Saha, 2017. "Economic Burden of Obesity: A Systematic Literature Review," IJERPH, MDPI, vol. 14(4), pages 1-18, April.

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