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The amino acid sensor GCN2 controls gut inflammation by inhibiting inflammasome activation

Author

Listed:
  • Rajesh Ravindran

    (Emory Vaccine Center, Yerkes National Primate Research Center)

  • Jens Loebbermann

    (Emory Vaccine Center, Yerkes National Primate Research Center)

  • Helder I. Nakaya

    (School of Pharmaceutical Sciences, University of São Paulo)

  • Nooruddin Khan

    (School of Life Sciences, University of Hyderabad)

  • Hualing Ma

    (Emory Vaccine Center, Yerkes National Primate Research Center)

  • Leonardo Gama

    (School of Pharmaceutical Sciences, University of São Paulo)

  • Deepa K. Machiah

    (Yerkes National Primate Research Center)

  • Benton Lawson

    (Virology Core, Emory Vaccine Center and Yerkes National Primate Research Center)

  • Paul Hakimpour

    (Emory Vaccine Center, Yerkes National Primate Research Center)

  • Yi-chong Wang

    (Emory Vaccine Center, Yerkes National Primate Research Center)

  • Shuzhao Li

    (Emory Vaccine Center, Yerkes National Primate Research Center)

  • Prachi Sharma

    (Yerkes National Primate Research Center)

  • Randal J. Kaufman

    (Degenerative Disease Program, Sanford Burnham Prebys Medical Discovery Institute)

  • Jennifer Martinez

    (National Institute of Environmental Health Sciences)

  • Bali Pulendran

    (Emory Vaccine Center, Yerkes National Primate Research Center)

Abstract

The GCN2 kinase is shown to have a protective role in the regulation of intestinal inflammation during amino acid starvation in a mouse model of colitis.

Suggested Citation

  • Rajesh Ravindran & Jens Loebbermann & Helder I. Nakaya & Nooruddin Khan & Hualing Ma & Leonardo Gama & Deepa K. Machiah & Benton Lawson & Paul Hakimpour & Yi-chong Wang & Shuzhao Li & Prachi Sharma & , 2016. "The amino acid sensor GCN2 controls gut inflammation by inhibiting inflammasome activation," Nature, Nature, vol. 531(7595), pages 523-527, March.
    • Handle: RePEc:nat:nature:v:531:y:2016:i:7595:d:10.1038_nature17186
    DOI: 10.1038/nature17186
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    Cited by:

    1. Eva K. Lee & Helder I. Nakaya & Fan Yuan & Troy D. Querec & Greg Burel & Ferdinand H. Pietz & Bernard A. Benecke & Bali Pulendran, 2016. "Machine Learning for Predicting Vaccine Immunogenicity," Interfaces, INFORMS, vol. 46(5), pages 368-390, October.

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