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PGC1α drives NAD biosynthesis linking oxidative metabolism to renal protection

Author

Listed:
  • Mei T. Tran

    (Beth Israel Deaconess Medical Center and Harvard Medical School
    Center for Vascular Biology Research, Beth Israel Deaconess Medical Center and Harvard Medical School)

  • Zsuzsanna K. Zsengeller

    (Beth Israel Deaconess Medical Center and Harvard Medical School
    Center for Vascular Biology Research, Beth Israel Deaconess Medical Center and Harvard Medical School
    Beth Israel Deaconess Medical Center and Harvard Medical School)

  • Anders H. Berg

    (Beth Israel Deaconess Medical Center and Harvard Medical School
    Beth Israel Deaconess Medical Center and Harvard Medical School)

  • Eliyahu V. Khankin

    (Beth Israel Deaconess Medical Center and Harvard Medical School
    Center for Vascular Biology Research, Beth Israel Deaconess Medical Center and Harvard Medical School)

  • Manoj K. Bhasin

    (Center for Vascular Biology Research, Beth Israel Deaconess Medical Center and Harvard Medical School
    Bioinformatics and Systems Biology Core, Beth Israel Deaconess Medical Center and Harvard Medical School)

  • Wondong Kim

    (Massachusetts General Hospital and Harvard Medical School)

  • Clary B. Clish

    (Broad Institute of MIT and Harvard)

  • Isaac E. Stillman

    (Beth Israel Deaconess Medical Center and Harvard Medical School)

  • S. Ananth Karumanchi

    (Beth Israel Deaconess Medical Center and Harvard Medical School
    Center for Vascular Biology Research, Beth Israel Deaconess Medical Center and Harvard Medical School
    Howard Hughes Medical Institute)

  • Eugene P. Rhee

    (Massachusetts General Hospital and Harvard Medical School
    Broad Institute of MIT and Harvard)

  • Samir M. Parikh

    (Beth Israel Deaconess Medical Center and Harvard Medical School
    Center for Vascular Biology Research, Beth Israel Deaconess Medical Center and Harvard Medical School)

Abstract

PGC1α protects against kidney injury by upregulating enzymes that enhance nicotinamide adenine dinucleotide (NAD) and driving local accumulation of the fatty acid breakdown product β-hydroxybutyrate, which leads to increased production of the renoprotective prostaglandin E2.

Suggested Citation

  • Mei T. Tran & Zsuzsanna K. Zsengeller & Anders H. Berg & Eliyahu V. Khankin & Manoj K. Bhasin & Wondong Kim & Clary B. Clish & Isaac E. Stillman & S. Ananth Karumanchi & Eugene P. Rhee & Samir M. Pari, 2016. "PGC1α drives NAD biosynthesis linking oxidative metabolism to renal protection," Nature, Nature, vol. 531(7595), pages 528-532, March.
    • Handle: RePEc:nat:nature:v:531:y:2016:i:7595:d:10.1038_nature17184
    DOI: 10.1038/nature17184
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    Cited by:

    1. Markus M. Rinschen & Oleg Palygin & Ashraf El-Meanawy & Xavier Domingo-Almenara & Amelia Palermo & Lashodya V. Dissanayake & Daria Golosova & Michael A. Schafroth & Carlos Guijas & Fatih Demir & Johan, 2022. "Accelerated lysine metabolism conveys kidney protection in salt-sensitive hypertension," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    2. Yunwen Yang & Suwen Liu & Peipei Wang & Jing Ouyang & Ning Zhou & Yue Zhang & Songming Huang & Zhanjun Jia & Aihua Zhang, 2023. "DNA-dependent protein kinase catalytic subunit (DNA-PKcs) drives chronic kidney disease progression in male mice," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    3. Koki Mise & Jianyin Long & Daniel L. Galvan & Zengchun Ye & Guizhen Fan & Rajesh Sharma & Irina I. Serysheva & Travis I. Moore & Collene R. Jeter & M. Anna Zal & Motoo Araki & Jun Wada & Paul T. Schum, 2024. "NDUFS4 regulates cristae remodeling in diabetic kidney disease," Nature Communications, Nature, vol. 15(1), pages 1-19, December.

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