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Sequence-dependent but not sequence-specific piRNA adhesion traps mRNAs to the germ plasm

Author

Listed:
  • Anastassios Vourekas

    (Institute for Translational Medicine and Therapeutics, Perelman School of Medicine; PENN Genome Frontiers Institute, University of Pennsylvania
    PENN Genome Frontiers Institute, University of Pennsylvania)

  • Panagiotis Alexiou

    (Institute for Translational Medicine and Therapeutics, Perelman School of Medicine; PENN Genome Frontiers Institute, University of Pennsylvania
    PENN Genome Frontiers Institute, University of Pennsylvania)

  • Nicholas Vrettos

    (Institute for Translational Medicine and Therapeutics, Perelman School of Medicine; PENN Genome Frontiers Institute, University of Pennsylvania
    PENN Genome Frontiers Institute, University of Pennsylvania)

  • Manolis Maragkakis

    (Institute for Translational Medicine and Therapeutics, Perelman School of Medicine; PENN Genome Frontiers Institute, University of Pennsylvania
    PENN Genome Frontiers Institute, University of Pennsylvania)

  • Zissimos Mourelatos

    (Institute for Translational Medicine and Therapeutics, Perelman School of Medicine; PENN Genome Frontiers Institute, University of Pennsylvania
    PENN Genome Frontiers Institute, University of Pennsylvania)

Abstract

Maternal mRNAs are tethered within the Drosophila germ plasm via base-pairing interactions between mRNAs and piRNPs containing the Aub Piwi protein; the preference for certain mRNAs to be tethered appears to be related to their longer length, which provides more potential piRNP-binding sites, and the results suggest a new role for piRNAs in germ-cell specification independent of their role in transposon silencing.

Suggested Citation

  • Anastassios Vourekas & Panagiotis Alexiou & Nicholas Vrettos & Manolis Maragkakis & Zissimos Mourelatos, 2016. "Sequence-dependent but not sequence-specific piRNA adhesion traps mRNAs to the germ plasm," Nature, Nature, vol. 531(7594), pages 390-394, March.
    • Handle: RePEc:nat:nature:v:531:y:2016:i:7594:d:10.1038_nature17150
    DOI: 10.1038/nature17150
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