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The C. elegans adult neuronal IIS/FOXO transcriptome reveals adult phenotype regulators

Author

Listed:
  • Rachel Kaletsky

    (Princeton University)

  • Vanisha Lakhina

    (Princeton University)

  • Rachel Arey

    (Princeton University)

  • April Williams

    (Princeton University)

  • Jessica Landis

    (Princeton University)

  • Jasmine Ashraf

    (Princeton University)

  • Coleen T. Murphy

    (Princeton University)

Abstract

The FOXO transcription factor, DAF-16, is required for the long-life phenotype of daf-2 mutant nematode worms; here the authors find that daf-2 mutant worms maintain neuronal functions and behaviours with age by using a set of transcriptional targets that are distinct from previously identified canonical FOXO/DAF-16-regulated targets.

Suggested Citation

  • Rachel Kaletsky & Vanisha Lakhina & Rachel Arey & April Williams & Jessica Landis & Jasmine Ashraf & Coleen T. Murphy, 2016. "The C. elegans adult neuronal IIS/FOXO transcriptome reveals adult phenotype regulators," Nature, Nature, vol. 529(7584), pages 92-96, January.
    • Handle: RePEc:nat:nature:v:529:y:2016:i:7584:d:10.1038_nature16483
    DOI: 10.1038/nature16483
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