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Rational design of α-helical tandem repeat proteins with closed architectures

Author

Listed:
  • Lindsey Doyle

    (Fred Hutchinson Cancer Research Center)

  • Jazmine Hallinan

    (Fred Hutchinson Cancer Research Center)

  • Jill Bolduc

    (Fred Hutchinson Cancer Research Center)

  • Fabio Parmeggiani

    (University of Washington
    Institute for Protein Design, University of Washington)

  • David Baker

    (University of Washington
    Institute for Protein Design, University of Washington
    Howard Hughes Medical Institute, University of Washington)

  • Barry L. Stoddard

    (Fred Hutchinson Cancer Research Center)

  • Philip Bradley

    (Fred Hutchinson Cancer Research Center
    Institute for Protein Design, University of Washington
    Fred Hutchinson Cancer Research Center)

Abstract

The development and validation of computational methods for geometry-guided de novo design of tandem repeat protein architectures.

Suggested Citation

  • Lindsey Doyle & Jazmine Hallinan & Jill Bolduc & Fabio Parmeggiani & David Baker & Barry L. Stoddard & Philip Bradley, 2015. "Rational design of α-helical tandem repeat proteins with closed architectures," Nature, Nature, vol. 528(7583), pages 585-588, December.
    • Handle: RePEc:nat:nature:v:528:y:2015:i:7583:d:10.1038_nature16191
    DOI: 10.1038/nature16191
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    Cited by:

    1. Lindsey A. Doyle & Brittany Takushi & Ryan D. Kibler & Lukas F. Milles & Carolina T. Orozco & Jonathan D. Jones & Sophie E. Jackson & Barry L. Stoddard & Philip Bradley, 2023. "De novo design of knotted tandem repeat proteins," Nature Communications, Nature, vol. 14(1), pages 1-17, December.

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