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Replication stress activates DNA repair synthesis in mitosis

Author

Listed:
  • Sheroy Minocherhomji

    (Center for Chromosome Stability and Center for Healthy Aging, University of Copenhagen, Panum Institute)

  • Songmin Ying

    (Zhejiang University School of Medicine
    Zhejiang University School of Medicine)

  • Victoria A. Bjerregaard

    (Center for Chromosome Stability and Center for Healthy Aging, University of Copenhagen, Panum Institute)

  • Sara Bursomanno

    (Center for Chromosome Stability and Center for Healthy Aging, University of Copenhagen, Panum Institute)

  • Aiste Aleliunaite

    (Center for Chromosome Stability and Center for Healthy Aging, University of Copenhagen, Panum Institute)

  • Wei Wu

    (Center for Chromosome Stability and Center for Healthy Aging, University of Copenhagen, Panum Institute)

  • Hocine W. Mankouri

    (Center for Chromosome Stability and Center for Healthy Aging, University of Copenhagen, Panum Institute)

  • Huahao Shen

    (Zhejiang University School of Medicine
    State Key Laboratory of Respiratory Disease (SKLRD))

  • Ying Liu

    (Center for Chromosome Stability and Center for Healthy Aging, University of Copenhagen, Panum Institute)

  • Ian D. Hickson

    (Center for Chromosome Stability and Center for Healthy Aging, University of Copenhagen, Panum Institute)

Abstract

Common fragile sites (CFSs) are difficult-to-replicate regions of eukaryotic genomes that are sensitive to replication stress and that require resolution by the MUS81–EME1 endonuclease to re-initiate POLD3-dependent DNA synthesis in early mitosis; this study defines the specific pathway of events causing the CFS fragility phenotype.

Suggested Citation

  • Sheroy Minocherhomji & Songmin Ying & Victoria A. Bjerregaard & Sara Bursomanno & Aiste Aleliunaite & Wei Wu & Hocine W. Mankouri & Huahao Shen & Ying Liu & Ian D. Hickson, 2015. "Replication stress activates DNA repair synthesis in mitosis," Nature, Nature, vol. 528(7581), pages 286-290, December.
    • Handle: RePEc:nat:nature:v:528:y:2015:i:7581:d:10.1038_nature16139
    DOI: 10.1038/nature16139
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    Cited by:

    1. Anne Margriet Heijink & Colin Stok & David Porubsky & Eleni Maria Manolika & Jurrian K. Kanter & Yannick P. Kok & Marieke Everts & H. Rudolf Boer & Anastasia Audrey & Femke J. Bakker & Elles Wierenga , 2022. "Sister chromatid exchanges induced by perturbed replication can form independently of BRCA1, BRCA2 and RAD51," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    2. Lorenza Garribba & Giuseppina De Feudis & Valentino Martis & Martina Galli & Marie Dumont & Yonatan Eliezer & René Wardenaar & Marica Rosaria Ippolito & Divya Ramalingam Iyer & Andréa E. Tijhuis & Dia, 2023. "Short-term molecular consequences of chromosome mis-segregation for genome stability," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    3. Ronan Broderick & Veronica Cherdyntseva & Jadwiga Nieminuszczy & Eleni Dragona & Maria Kyriakaki & Theodora Evmorfopoulou & Sarantis Gagos & Wojciech Niedzwiedz, 2023. "Pathway choice in the alternative telomere lengthening in neoplasia is dictated by replication fork processing mediated by EXD2’s nuclease activity," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    4. Frederick Richards & Marta J. Llorca-Cardenosa & Jamie Langton & Sara C. Buch-Larsen & Noor F. Shamkhi & Abhishek Bharadwaj Sharma & Michael L. Nielsen & Nicholas D. Lakin, 2023. "Regulation of Rad52-dependent replication fork recovery through serine ADP-ribosylation of PolD3," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    5. Zhengcheng He & Ryan Ghorayeb & Susanna Tan & Ke Chen & Amanda C. Lorentzian & Jack Bottyan & Syed Mohammed Musheer Aalam & Miguel Angel Pujana & Philipp F. Lange & Nagarajan Kannan & Connie J. Eaves , 2022. "Pathogenic BRCA1 variants disrupt PLK1-regulation of mitotic spindle orientation," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    6. Martin Andrs & Henriette Stoy & Barbora Boleslavska & Nagaraja Chappidi & Radhakrishnan Kanagaraj & Zuzana Nascakova & Shruti Menon & Satyajeet Rao & Anna Oravetzova & Jana Dobrovolna & Kalpana Surend, 2023. "Excessive reactive oxygen species induce transcription-dependent replication stress," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    7. Sameer Bikram Shah & Youhang Li & Shibo Li & Qing Hu & Tong Wu & Yanmeng Shi & Tran Nguyen & Isaac Ive & Linda Shi & Hailong Wang & Xiaohua Wu, 2024. "53BP1 deficiency leads to hyperrecombination using break-induced replication (BIR)," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    8. Daniela Muoio & Natalie Laspata & Rachel L. Dannenberg & Caroline Curry & Simone Darkoa-Larbi & Mark Hedglin & Shikhar Uttam & Elise Fouquerel, 2024. "PARP2 promotes Break Induced Replication-mediated telomere fragility in response to replication stress," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    9. Thomas E. Wilson & Samreen Ahmed & Amanda Winningham & Thomas W. Glover, 2024. "Replication stress induces POLQ-mediated structural variant formation throughout common fragile sites after entry into mitosis," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    10. Wei Wu & Szymon A. Barwacz & Rahul Bhowmick & Katrine Lundgaard & Marisa M. Gonçalves Dinis & Malgorzata Clausen & Masato T. Kanemaki & Ying Liu, 2023. "Mitotic DNA synthesis in response to replication stress requires the sequential action of DNA polymerases zeta and delta in human cells," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    11. Anastasiya Kishkevich & Sanjeeta Tamang & Michael O. Nguyen & Judith Oehler & Elena Bulmaga & Christos Andreadis & Carl A. Morrow & Manisha Jalan & Fekret Osman & Matthew C. Whitby, 2022. "Rad52’s DNA annealing activity drives template switching associated with restarted DNA replication," Nature Communications, Nature, vol. 13(1), pages 1-13, December.

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