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Hallmarks of pluripotency

Author

Listed:
  • Alejandro De Los Angeles

    (Stem Cell Transplantation Program, Children’s Hospital Boston, Harvard Medical School
    Harvard Medical School
    Harvard Stem Cell Institute
    Howard Hughes Medical Institute)

  • Francesco Ferrari

    (Harvard Medical School)

  • Ruibin Xi

    (Harvard Medical School
    School of Mathematical Sciences and Center for Statistical Science, Peking University)

  • Yuko Fujiwara

    (Stem Cell Transplantation Program, Children’s Hospital Boston, Harvard Medical School
    Harvard Medical School
    Harvard Stem Cell Institute
    Howard Hughes Medical Institute)

  • Nissim Benvenisty

    (Stem Cell Unit, Institute of Life Sciences, The Hebrew University)

  • Hongkui Deng

    (College of Life Sciences and Peking-Tsinghua Center for Life Sciences, Peking University)

  • Konrad Hochedlinger

    (Harvard Stem Cell Institute
    Howard Hughes Medical Institute
    Harvard Medical School
    Massachusetts General Hospital Cancer Center and Center for Regenerative Medicine)

  • Rudolf Jaenisch

    (Whitehead Institute for Biomedical Research)

  • Soohyun Lee

    (Harvard Medical School)

  • Harry G. Leitch

    (Medical Research Council Clinical Sciences Centre, Imperial College London)

  • M. William Lensch

    (Stem Cell Transplantation Program, Children’s Hospital Boston, Harvard Medical School
    Harvard Medical School
    Harvard Stem Cell Institute
    Howard Hughes Medical Institute)

  • Ernesto Lujan

    (Institute for Stem Cell Biology and Regenerative Medicine, Stanford University)

  • Duanqing Pei

    (South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences)

  • Janet Rossant

    (The Hospital for Sick Children Research Institute)

  • Marius Wernig

    (Institute for Stem Cell Biology and Regenerative Medicine, Stanford University)

  • Peter J. Park

    (Harvard Medical School)

  • George Q. Daley

    (Stem Cell Transplantation Program, Children’s Hospital Boston, Harvard Medical School
    Harvard Medical School
    Harvard Stem Cell Institute
    Howard Hughes Medical Institute)

Abstract

In response to the need for a defined set of criteria to assess stem-cell potency, this review proposes guidelines for the evaluation of newly derived pluripotent stem cells, from functional assays to integrative molecular analyses of transcriptional, epigenetic and metabolic states.

Suggested Citation

  • Alejandro De Los Angeles & Francesco Ferrari & Ruibin Xi & Yuko Fujiwara & Nissim Benvenisty & Hongkui Deng & Konrad Hochedlinger & Rudolf Jaenisch & Soohyun Lee & Harry G. Leitch & M. William Lensch , 2015. "Hallmarks of pluripotency," Nature, Nature, vol. 525(7570), pages 469-478, September.
    • Handle: RePEc:nat:nature:v:525:y:2015:i:7570:d:10.1038_nature15515
    DOI: 10.1038/nature15515
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    Cited by:

    1. Joyce J. Thompson & Daniel J. Lee & Apratim Mitra & Sarah Frail & Ryan K. Dale & Pedro P. Rocha, 2022. "Extensive co-binding and rapid redistribution of NANOG and GATA6 during emergence of divergent lineages," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    2. Maria Arez & Melanie Eckersley-Maslin & Tajda Klobučar & João Gilsa Lopes & Felix Krueger & Annalisa Mupo & Ana Cláudia Raposo & David Oxley & Samantha Mancino & Anne-Valerie Gendrel & Bruno Bernardes, 2022. "Imprinting fidelity in mouse iPSCs depends on sex of donor cell and medium formulation," Nature Communications, Nature, vol. 13(1), pages 1-20, December.
    3. Sébastien Durand & Marion Bruelle & Fleur Bourdelais & Bigitha Bennychen & Juliana Blin-Gonthier & Caroline Isaac & Aurélia Huyghe & Sylvie Martel & Antoine Seyve & Christophe Vanbelle & Annie Adrait , 2023. "RSL24D1 sustains steady-state ribosome biogenesis and pluripotency translational programs in embryonic stem cells," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    4. Mattia Zaghi & Federica Banfi & Luca Massimino & Monica Volpin & Edoardo Bellini & Simone Brusco & Ivan Merelli & Cristiana Barone & Michela Bruni & Linda Bossini & Luigi Antonio Lamparelli & Laura Pi, 2023. "Balanced SET levels favor the correct enhancer repertoire during cell fate acquisition," Nature Communications, Nature, vol. 14(1), pages 1-21, December.

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