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Tet2 is required to resolve inflammation by recruiting Hdac2 to specifically repress IL-6

Author

Listed:
  • Qian Zhang

    (Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences
    National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University)

  • Kai Zhao

    (Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences)

  • Qicong Shen

    (National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University)

  • Yanmei Han

    (National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University)

  • Yan Gu

    (National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University)

  • Xia Li

    (Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences)

  • Dezhi Zhao

    (Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences)

  • Yiqi Liu

    (National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University)

  • Chunmei Wang

    (Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences)

  • Xiang Zhang

    (National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University)

  • Xiaoping Su

    (National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University)

  • Juan Liu

    (National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University)

  • Wei Ge

    (Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences)

  • Ross L. Levine

    (Human Oncology and Pathogenesis Program and Leukemia Service, Memorial Sloan-Kettering Cancer)

  • Nan Li

    (National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University)

  • Xuetao Cao

    (Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences
    National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University)

Abstract

The Tet2 enzyme, which catalyses de novo hydroxymethylation of DNA, is shown here to act as a transcriptional repressor by recruiting the histone deacetylase Hdac2 to the Il6 promoter in the course of resolution of the LPS-induced inflammatory response.

Suggested Citation

  • Qian Zhang & Kai Zhao & Qicong Shen & Yanmei Han & Yan Gu & Xia Li & Dezhi Zhao & Yiqi Liu & Chunmei Wang & Xiang Zhang & Xiaoping Su & Juan Liu & Wei Ge & Ross L. Levine & Nan Li & Xuetao Cao, 2015. "Tet2 is required to resolve inflammation by recruiting Hdac2 to specifically repress IL-6," Nature, Nature, vol. 525(7569), pages 389-393, September.
    • Handle: RePEc:nat:nature:v:525:y:2015:i:7569:d:10.1038_nature15252
    DOI: 10.1038/nature15252
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    Cited by:

    1. Steffen Mueller & Gail Dennison & Shujun Liu, 2021. "An Assessment on Ethanol-Blended Gasoline/Diesel Fuels on Cancer Risk and Mortality," IJERPH, MDPI, vol. 18(13), pages 1-23, June.
    2. Amadou Gaye & Gary H Gibbons & Charles Barry & Rakale Quarells & Sharon K Davis, 2017. "Influence of socioeconomic status on the whole blood transcriptome in African Americans," PLOS ONE, Public Library of Science, vol. 12(12), pages 1-15, December.
    3. Jiacheng Wu & Xiaoqing Xu & Jiaqi Duan & Yangyang Chai & Jiaying Song & Dongsheng Gong & Bingjing Wang & Ye Hu & Taotao Han & Yuanyuan Ding & Yin Liu & Jingnan Li & Xuetao Cao, 2024. "EFHD2 suppresses intestinal inflammation by blocking intestinal epithelial cell TNFR1 internalization and cell death," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    4. Antonia Kolb & Ana-Marija Kulis-Mandic & Matthias Klein & Anna Stastny & Maximilian Haist & Vanessa Votteler & Beate Weidenthaler-Barth & Tobias Sinnberg & Antje Sucker & Gabriele Allies & Lea Jessica, 2025. "Constitutive expression of the transcriptional co-activator IκBζ promotes melanoma growth and immunotherapy resistance," Nature Communications, Nature, vol. 16(1), pages 1-19, December.

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