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Sidekick 2 directs formation of a retinal circuit that detects differential motion

Author

Listed:
  • Arjun Krishnaswamy

    (Harvard University)

  • Masahito Yamagata

    (Harvard University)

  • Xin Duan

    (Harvard University)

  • Y. Kate Hong

    (Harvard University
    † Present address: Department of Neuroscience, Columbia University, New York 10032, USA.)

  • Joshua R. Sanes

    (Harvard University)

Abstract

The mouse retinal ganglion cell type known as the W3B-RGC, which detects motion of objects against a moving background, is shown to receive strong specific and excitatory input from amacrine cells expressing vesicular glutamine transporter 3; this selective connection is mediated by homophilic interactions of the recognition molecule sidekick 2 (Sdk2), which is expressed on both cells, and disruption of this connection affects object motion detection in W3B-RGCs.

Suggested Citation

  • Arjun Krishnaswamy & Masahito Yamagata & Xin Duan & Y. Kate Hong & Joshua R. Sanes, 2015. "Sidekick 2 directs formation of a retinal circuit that detects differential motion," Nature, Nature, vol. 524(7566), pages 466-470, August.
    • Handle: RePEc:nat:nature:v:524:y:2015:i:7566:d:10.1038_nature14682
    DOI: 10.1038/nature14682
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