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Directional dominance on stature and cognition in diverse human populations

Author

Listed:
  • Peter K. Joshi

    (Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh)

  • Tonu Esko

    (Estonian Genome Center, University of Tartu
    Boston Children's Hospital
    Program in Medical and Population Genetics, Broad Institute
    Harvard Medical School)

  • Hannele Mattsson

    (Unit of Public Health Genomics, National Institute for Health and Welfare
    Institute for Molecular Medicine Finland (FIMM), University of Helsinki)

  • Niina Eklund

    (Unit of Public Health Genomics, National Institute for Health and Welfare)

  • Ilaria Gandin

    (University of Trieste)

  • Teresa Nutile

    (Institute of Genetics and Biophysics “A. Buzzati-Traverso” CNR)

  • Anne U. Jackson

    (University of Michigan)

  • Claudia Schurmann

    (The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai
    The Genetics of Obesity and Related Metabolic Traits Program, Icahn School of Medicine at Mount Sinai)

  • Albert V. Smith

    (Icelandic Heart Association
    Faculty of Medicine, University of Iceland)

  • Weihua Zhang

    (Imperial College London
    Ealing Hospital NHS Trust)

  • Yukinori Okada

    (Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University
    Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences)

  • Alena Stančáková

    (University of Eastern Finland)

  • Jessica D. Faul

    (Institute for Social Research, University of Michigan)

  • Wei Zhao

    (University of Michigan)

  • Traci M. Bartz

    (Cardiovascular Health Research Unit, University of Washington)

  • Maria Pina Concas

    (Institute of Population Genetics, National Research Council)

  • Nora Franceschini

    (Epidemiology, University of North Carolina)

  • Stefan Enroth

    (Genetics, and Pathology, Biomedical Center, SciLifeLab Uppsala, Uppsala University)

  • Veronique Vitart

    (MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh)

  • Stella Trompet

    (Leiden University Medical Center)

  • Xiuqing Guo

    (Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute
    Harbor-UCLA Medical Center)

  • Daniel I. Chasman

    (Brigham and Women's Hospital)

  • Jeffrey R. O'Connel

    (Diabetes, and Nutrition and Program for Personalised and Genomic Medicine, University of Maryland School of Medicine)

  • Tanguy Corre

    (University of Lausanne
    Swiss Institute of Bioinformatics, Quartier Sorge - batiment génopode)

  • Suraj S. Nongmaithem

    (Genomic Research on Complex Diseases (GRC) Group, CSIR-Centre for Cellular and Molecular Biology, Habshiguda)

  • Yuning Chen

    (Boston University School of Public Health)

  • Massimo Mangino

    (King's College London
    NIHR Biomedical Research Centre, Guy's and St. Thomas' Foundation Trust)

  • Daniela Ruggiero

    (Institute of Genetics and Biophysics “A. Buzzati-Traverso” CNR)

  • Michela Traglia

    (San Raffaele Scientific Institute)

  • Aliki-Eleni Farmaki

    (Harokopio University of Athens)

  • Tim Kacprowski

    (Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald)

  • Andrew Bjonnes

    (Center for Human Genetic Research)

  • Ashley van der Spek

    (Erasmus Medical Center)

  • Ying Wu

    (University of North Carolina)

  • Anil K. Giri

    (Genomics and Molecular Medicine, CSIR-Institute of Genomics & Integrative Biology)

  • Lisa R. Yanek

    (The GeneSTAR Research Program, The Johns Hopkins University School of Medicine)

  • Lihua Wang

    (Washington University School of Medicine)

  • Edith Hofer

    (Medical University Graz
    Institute for Medical Informatics, Statistics and Documentation, Medical University Graz)

  • Cornelius A. Rietveld

    (Erasmus School of Economics, Erasmus University Rotterdam)

  • Olga McLeod

    (Atherosclerosis Research Unit, Karolinska Institutet)

  • Marilyn C. Cornelis

    (Brigham & Women's Hospital
    Nutrition, Harvard School of Public Health)

  • Cristian Pattaro

    (Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), 39100 Bolzano, Italy (affiliated Institute of the University of Lübeck, D-23562 Lübeck, Germany).)

  • Niek Verweij

    (University of Groningen, University Medical Center Groningen)

  • Clemens Baumbach

    (Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
    Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health
    Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health)

  • Abdel Abdellaoui

    (VU University Amsterdam)

  • Helen R. Warren

    (Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London
    NIHR Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London)

  • Dragana Vuckovic

    (University of Trieste)

  • Hao Mei

    (University of Mississippi Medical Center)

  • Claude Bouchard

    (Pennington Biomedical Research Center)

  • John R. B. Perry

    (MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus)

  • Stefania Cappellani

    (Institute for Maternal and Child Health - IRCCS “Burlo Garofolo”)

  • Saira S. Mirza

    (Erasmus Medical Center)

  • Miles C. Benton

    (Institute of Health and Biomedical Innovation, Queensland University of Technology)

  • Ulrich Broeckel

    (Medical College of Wisconsin)

  • Sarah E. Medland

    (Quantitative Genetics, QIMR Berghofer Medical Research Institute)

  • Penelope A. Lind

    (Quantitative Genetics, QIMR Berghofer Medical Research Institute)

  • Giovanni Malerba

    (University of Verona)

  • Alexander Drong

    (Wellcome Trust Centre for Human Genetics, University of Oxford)

  • Loic Yengo

    (CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Lille 2 University)

  • Lawrence F. Bielak

    (University of Michigan)

  • Degui Zhi

    (University of Alabama at Birmingham)

  • Peter J. van der Most

    (University of Groningen, University Medical Center Groningen, Groningen)

  • Daniel Shriner

    (Center for Research on Genomics and Global Health, National Human Genome Research Institute)

  • Reedik Mägi

    (Estonian Genome Center, University of Tartu)

  • Gibran Hemani

    (MRC Integrative Epidemiology Unit, University of Bristol)

  • Tugce Karaderi

    (Wellcome Trust Centre for Human Genetics, University of Oxford)

  • Zhaoming Wang

    (National Cancer Institute, National Institutes of Health
    Cancer Genomics Research Laboratory, National Cancer Institute, SAIC-Frederick, Inc., Frederick National Laboratory for Cancer Research)

  • Tian Liu

    (Center for Lifespan Psychology, Max Planck Institute for Human Development
    Vertebrate Genomics, Max Planck Institute for Molecular Genetics)

  • Ilja Demuth

    (Charité Research Group on Geriatrics, Charité – Universitätsmedizin Berlin
    Institute of Medical and Human Genetics, Charité – Universitätsmedizin Berlin)

  • Jing Hua Zhao

    (MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus)

  • Weihua Meng

    (Medical Research Institute, University of Dundee)

  • Lazaros Lataniotis

    (William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London)

  • Sander W. van der Laan

    (Experimental Cardiology, University Medical Center Utrecht)

  • Jonathan P. Bradfield

    (Center for Applied Genomics, Children's Hospital of Philadelphia)

  • Andrew R. Wood

    (Genetics of Complex Traits, University of Exeter Medical School, University of Exeter)

  • Amelie Bonnefond

    (CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Lille 2 University)

  • Tarunveer S. Ahluwalia

    (COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen
    Novo Nordisk Centre for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen
    Steno Diabetes Centre, Niels Steensens Vej 2)

  • Leanne M. Hall

    (University of Leicester, BHF Cardiovascular Research Centre)

  • Erika Salvi

    (University of Milan)

  • Seyhan Yazar

    (Centre for Ophthalmology and Visual Science, University of Western Australia, Lions Eye Institute)

  • Lisbeth Carstensen

    (Statens Serum Institut)

  • Hugoline G. de Haan

    (Clinical Epidemiology, Leiden University Medical Center)

  • Mark Abney

    (University of Chicago)

  • Uzma Afzal

    (Imperial College London
    Ealing Hospital NHS Trust)

  • Matthew A. Allison

    (University of California San Diego)

  • Najaf Amin

    (Erasmus Medical Center)

  • Folkert W. Asselbergs

    (University Medical Center Utrecht
    Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute
    Institute of Cardiovascular Science, faculty of Population Health Sciences, University College London)

  • Stephan J. L. Bakker

    (University of Groningen, University Medical Center Groningen)

  • R. Graham Barr

    (Columbia University)

  • Sebastian E. Baumeister

    (Institute for Community Medicine, University Medicine Greifswald)

  • Daniel J. Benjamin

    (Cornell University
    University of Southern California)

  • Sven Bergmann

    (University of Lausanne
    Swiss Institute of Bioinformatics, Quartier Sorge - batiment génopode)

  • Eric Boerwinkle

    (Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston)

  • Erwin P. Bottinger

    (The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai)

  • Archie Campbell

    (Centre for Genomic and Experimental Medicine, University of Edinburgh)

  • Aravinda Chakravarti

    (McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine)

  • Yingleong Chan

    (Boston Children's Hospital
    Program in Medical and Population Genetics, Broad Institute
    Harvard Medical School)

  • Stephen J. Chanock

    (National Cancer Institute, National Institutes of Health)

  • Constance Chen

    (Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health)

  • Y.-D. Ida Chen

    (Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute
    Harbor-UCLA Medical Center)

  • Francis S. Collins

    (Genome Technology Branch, National Human Genome Research Institute, NIH)

  • John Connell

    (College of Medicine, Dentistry and Nursing, Ninewells Hospital and Medical School)

  • Adolfo Correa

    (University of Mississippi Medical Center)

  • L. Adrienne Cupples

    (Boston University School of Public Health
    National Heart, Lung, and Blood Institute's Framingham Heart Study)

  • George Davey Smith

    (MRC Integrative Epidemiology Unit, University of Bristol)

  • Gail Davies

    (Psychology, University of Edinburgh
    Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh)

  • Marcus Dörr

    (University Medicine Greifswald)

  • Georg Ehret

    (McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine
    Cardiology, Geneva University Hospitals)

  • Stephen B. Ellis

    (The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai)

  • Bjarke Feenstra

    (Statens Serum Institut)

  • Mary F. Feitosa

    (Washington University School of Medicine)

  • Ian Ford

    (Robertson Centre, University of Glasgow)

  • Caroline S. Fox

    (National Heart, Lung, and Blood Institute's Framingham Heart Study
    Brigham and Women's Hospital and Harvard Medical School)

  • Timothy M. Frayling

    (Genetics of Complex Traits, University of Exeter Medical School, University of Exeter)

  • Nele Friedrich

    (Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald)

  • Frank Geller

    (Statens Serum Institut)

  • Generation Scotland

    (Centre for Genomic and Experimental Medicine, University of Edinburgh)

  • Irina Gillham-Nasenya

    (King's College London)

  • Omri Gottesman

    (The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai)

  • Misa Graff

    (Epidemiology, University of North Carolina)

  • Francine Grodstein

    (Nutrition, Harvard School of Public Health)

  • Charles Gu

    (Washington University)

  • Chris Haley

    (MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh
    Roslin Institute, University of Edinburgh)

  • Christopher J. Hammond

    (King's College London)

  • Sarah E. Harris

    (Centre for Genomic and Experimental Medicine, University of Edinburgh
    Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh)

  • Tamara B. Harris

    (National Institutes on Aging, National Institutes of Health)

  • Nicholas D. Hastie

    (MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh)

  • Nancy L. Heard-Costa

    (National Heart, Lung, and Blood Institute's Framingham Heart Study
    Boston University School of Medicine)

  • Kauko Heikkilä

    (University of Helsinki, Hjelt Institute)

  • Lynne J. Hocking

    (Musculoskeletal Research Programme, University of Aberdeen)

  • Georg Homuth

    (Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald)

  • Jouke-Jan Hottenga

    (VU University Amsterdam)

  • Jinyan Huang

    (State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital Affiliated with Shanghai Jiao Tong University School of Medicine)

  • Jennifer E. Huffman

    (MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh)

  • Pirro G. Hysi

    (King's College London)

  • M. Arfan Ikram

    (Erasmus Medical Center
    Erasmus Medical Center)

  • Erik Ingelsson

    (Wellcome Trust Centre for Human Genetics, University of Oxford
    Molecular Epidemiology and Science for Life Laboratory, Uppsala University)

  • Anni Joensuu

    (Unit of Public Health Genomics, National Institute for Health and Welfare
    Institute for Molecular Medicine Finland (FIMM), University of Helsinki)

  • Åsa Johansson

    (Genetics, and Pathology, Biomedical Center, SciLifeLab Uppsala, Uppsala University
    Uppsala Clinical Research Center, Uppsala University)

  • Pekka Jousilahti

    (National Institute for Health and Welfare)

  • J. Wouter Jukema

    (Leiden University Medical Center)

  • Mika Kähönen

    (University of Tampere and Tampere University Hospital)

  • Yoichiro Kamatani

    (Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences)

  • Stavroula Kanoni

    (William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London)

  • Shona M. Kerr

    (MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh)

  • Nazir M. Khan

    (Genomics and Molecular Medicine, CSIR-Institute of Genomics & Integrative Biology)

  • Philipp Koellinger

    (Erasmus School of Economics, Erasmus University Rotterdam)

  • Heikki A. Koistinen

    (Diabetes Prevention Unit, National Institute for Health and Welfare
    Helsinki University Central Hospital
    Minerva Foundation Institute for Medical Research)

  • Manraj K. Kooner

    (Ealing Hospital NHS Trust)

  • Michiaki Kubo

    (Laboratory for Genotyping Development RCfIMS)

  • Johanna Kuusisto

    (University of Eastern Finland and Kuopio University Hospital)

  • Jari Lahti

    (Institute of Behavioural Sciences, University of Helsinki
    Folkhälsan Reasearch Centre, PB 63, Helsinki, FI-00014 University of Helsinki)

  • Lenore J. Launer

    (National Institutes on Aging, National Institutes of Health)

  • Rodney A. Lea

    (Institute of Health and Biomedical Innovation, Queensland University of Technology)

  • Benjamin Lehne

    (Imperial College London)

  • Terho Lehtimäki

    (Fimlab Laboratories and School of Medicine University of Tampere)

  • David C.M. Liewald

    (Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh)

  • Lars Lind

    (University Hospital)

  • Marie Loh

    (Imperial College London
    Translational Laboratory in Genetic Medicine (TLGM), Agency for Science, Technology and Research (A*STAR))

  • Marja-Liisa Lokki

    (Transplantation laboratory, Haartman Institute, University of Helsinki)

  • Stephanie J. London

    (National Institute of Environmental Health Sciences, National Institutes of Health)

  • Stephanie J. Loomis

    (Ophthalmology, Massachusetts Eye and Ear)

  • Anu Loukola

    (University of Helsinki, Hjelt Institute)

  • Yingchang Lu

    (The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai
    The Genetics of Obesity and Related Metabolic Traits Program, Icahn School of Medicine at Mount Sinai)

  • Thomas Lumley

    (University of Auckland)

  • Annamari Lundqvist

    (Functional Capacity and Welfare, National Institute for Health and Welfare)

  • Satu Männistö

    (National Institute for Health and Welfare)

  • Pedro Marques-Vidal

    (University Hospital)

  • Corrado Masciullo

    (San Raffaele Scientific Institute)

  • Angela Matchan

    (Human Genetics, Wellcome Trust Sanger Institute, Hinxton)

  • Rasika A. Mathias

    (The GeneSTAR Research Program, The Johns Hopkins University School of Medicine
    The Johns Hopkins University School of Medicine)

  • Koichi Matsuda

    (Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo)

  • James B. Meigs

    (Massachusetts General Hospital)

  • Christa Meisinger

    (Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health)

  • Thomas Meitinger

    (Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health
    Institute of Human Genetics, Klinikum rechts der Isar, Technische Universität München)

  • Cristina Menni

    (King's College London)

  • Frank D. Mentch

    (Center for Applied Genomics, Children's Hospital of Philadelphia)

  • Evelin Mihailov

    (Estonian Genome Center, University of Tartu)

  • Lili Milani

    (Estonian Genome Center, University of Tartu)

  • May E. Montasser

    (Diabetes, and Nutrition and Program for Personalised and Genomic Medicine, University of Maryland School of Medicine)

  • Grant W. Montgomery

    (Molecular Epidemiology, QIMR Berghofer Medical Research Institute)

  • Alanna Morrison

    (Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston)

  • Richard H. Myers

    (Genome Science Institute, Boston University School of Medicine)

  • Rajiv Nadukuru

    (The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai)

  • Pau Navarro

    (MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh)

  • Mari Nelis

    (Estonian Genome Center, University of Tartu)

  • Markku S. Nieminen

    (HUCH Heart and Lung center, Helsinki University Central Hospital)

  • Ilja M. Nolte

    (University of Groningen, University Medical Center Groningen, Groningen)

  • George T. O'Connor

    (National Heart, Lung, and Blood Institute's Framingham Heart Study
    Boston University School of Medicine)

  • Adesola Ogunniyi

    (University of Ibadan)

  • Sandosh Padmanabhan

    (ICAMS, University of Glasgow)

  • Walter R. Palmas

    (Columbia University)

  • James S. Pankow

    (University of Minnesota)

  • Inga Patarcic

    (School of Medicine, University of Split)

  • Francesca Pavani

    (Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), 39100 Bolzano, Italy (affiliated Institute of the University of Lübeck, D-23562 Lübeck, Germany).)

  • Patricia A. Peyser

    (University of Michigan)

  • Kirsi Pietilainen

    (Institute for Molecular Medicine Finland (FIMM), University of Helsinki
    Helsinki University Central Hospital
    Obesity Research Unit, Research Programs Unit, Diabetes and Obesity, University of Helsinki)

  • Neil Poulter

    (International Centre for Circulatory Health, Imperial College London)

  • Inga Prokopenko

    (School of Public Health, Imperial College London)

  • Sarju Ralhan

    (Department of Cardiology and Cardio thoracic Surgery Hero DMC Heart Institute)

  • Paul Redmond

    (Psychology, University of Edinburgh)

  • Stephen S. Rich

    (University of Virginia School of Medicine)

  • Harri Rissanen

    (Functional Capacity and Welfare, National Institute for Health and Welfare)

  • Antonietta Robino

    (Institute for Maternal and Child Health - IRCCS “Burlo Garofolo”)

  • Lynda M. Rose

    (Brigham and Women's Hospital)

  • Richard Rose

    (Indiana University Bloomington)

  • Cinzia Sala

    (San Raffaele Scientific Institute)

  • Babatunde Salako

    (University of Ibadan)

  • Veikko Salomaa

    (National Institute for Health and Welfare)

  • Antti-Pekka Sarin

    (Unit of Public Health Genomics, National Institute for Health and Welfare
    Institute for Molecular Medicine Finland (FIMM), University of Helsinki)

  • Richa Saxena

    (Center for Human Genetic Research)

  • Helena Schmidt

    (Institute of Molecular Biology and Biochemistry, Medical University Graz)

  • Laura J. Scott

    (University of Michigan)

  • William R. Scott

    (Imperial College London
    Ealing Hospital NHS Trust)

  • Bengt Sennblad

    (Atherosclerosis Research Unit, Karolinska Institutet
    Science for Life Laboratory, Karolinska Institutet)

  • Sudha Seshadri

    (National Heart, Lung, and Blood Institute's Framingham Heart Study
    Boston University School of Medicine)

  • Peter Sever

    (International Centre for Circulatory Health, Imperial College London)

  • Smeeta Shrestha

    (Genomic Research on Complex Diseases (GRC) Group, CSIR-Centre for Cellular and Molecular Biology, Habshiguda)

  • Blair H. Smith

    (University of Dundee)

  • Jennifer A. Smith

    (University of Michigan)

  • Nicole Soranzo

    (Human Genetics, Wellcome Trust Sanger Institute, Hinxton)

  • Nona Sotoodehnia

    (Cardiovascular Health Research Unit, University of Washington)

  • Lorraine Southam

    (Wellcome Trust Centre for Human Genetics, University of Oxford
    Human Genetics, Wellcome Trust Sanger Institute, Hinxton)

  • Alice V. Stanton

    (Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, St. Stephen's Green)

  • Maria G. Stathopoulou

    (UMR INSERM U1122
    IGE-PCV “Interactions Gène-Environnement en Physiopathologie Cardio-Vasculaire”, INSERM, University of Lorraine)

  • Konstantin Strauch

    (Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
    Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology)

  • Rona J. Strawbridge

    (Atherosclerosis Research Unit, Karolinska Institutet)

  • Matthew J. Suderman

    (MRC Integrative Epidemiology Unit, University of Bristol)

  • Nikhil Tandon

    (All India Institute of Medical Sciences)

  • Sian-Tsun Tang

    (National Heart and Lung Institute, Imperial College London)

  • Kent D. Taylor

    (Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute
    Harbor-UCLA Medical Center)

  • Bamidele O. Tayo

    (Stritch School of Medicine, Loyola University Chicago)

  • Anna Maria Töglhofer

    (Institute of Molecular Biology and Biochemistry, Medical University Graz)

  • Maciej Tomaszewski

    (University of Leicester, BHF Cardiovascular Research Centre
    NIHR Leicester Cardiovascular Biomedical Research Unit, University of Leicester)

  • Natalia Tšernikova

    (Estonian Genome Center, University of Tartu
    Institute of Molecular and Cell Biology, University of Tartu)

  • Jaakko Tuomilehto

    (Diabetes Prevention Unit, National Institute for Health and Welfare
    Centre for Vascular Prevention, Danube-University Krems
    Diabetes Research Group, King Abdulaziz University)

  • Andre G. Uitterlinden

    (Erasmus Medical Center
    Erasmus Medical Center)

  • Dhananjay Vaidya

    (The GeneSTAR Research Program, The Johns Hopkins University School of Medicine
    Johns Hopkins Bloomberg School of Public Health)

  • Astrid van Hylckama Vlieg

    (Clinical Epidemiology, Leiden University Medical Center)

  • Jessica van Setten

    (Experimental Cardiology, University Medical Center Utrecht)

  • Tuula Vasankari

    (Finnish Lung Health Association)

  • Sailaja Vedantam

    (Boston Children's Hospital
    Program in Medical and Population Genetics, Broad Institute
    Harvard Medical School)

  • Efthymia Vlachopoulou

    (Transplantation laboratory, Haartman Institute, University of Helsinki)

  • Diego Vozzi

    (Institute for Maternal and Child Health - IRCCS “Burlo Garofolo”)

  • Eero Vuoksimaa

    (University of Helsinki, Hjelt Institute)

  • Melanie Waldenberger

    (Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
    Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health)

  • Erin B. Ware

    (University of Michigan)

  • William Wentworth-Shields

    (University of Chicago)

  • John B. Whitfield

    (Genetic Epidemiology, QIMR Berghofer Medical Research Institute)

  • Sarah Wild

    (Centre for Population Health Sciences, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh)

  • Gonneke Willemsen

    (VU University Amsterdam)

  • Chittaranjan S. Yajnik

    (Diabetes Unit, KEM Hospital and Research Centre, Rasta Peth, Pune, 411011, India.)

  • Jie Yao

    (Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute)

  • Gianluigi Zaza

    (Renal Unit, University of Verona)

  • Xiaofeng Zhu

    (Case Western Reserve University)

  • Rany M. Salem

    (Boston Children's Hospital
    Program in Medical and Population Genetics, Broad Institute
    Harvard Medical School)

  • Mads Melbye

    (Statens Serum Institut
    Stanford University)

  • Hans Bisgaard

    (COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen)

  • Nilesh J. Samani

    (University of Leicester, BHF Cardiovascular Research Centre
    NIHR Leicester Cardiovascular Biomedical Research Unit, University of Leicester)

  • Daniele Cusi

    (University of Milan)

  • David A. Mackey

    (Centre for Ophthalmology and Visual Science, University of Western Australia, Lions Eye Institute)

  • Richard S. Cooper

    (Stritch School of Medicine, Loyola University Chicago)

  • Philippe Froguel

    (CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Lille 2 University
    School of Public Health, Imperial College London)

  • Gerard Pasterkamp

    (Experimental Cardiology, University Medical Center Utrecht)

  • Struan F.A. Grant

    (Center for Applied Genomics, Children's Hospital of Philadelphia
    Perelman School of Medicine, The University of Pennsylvania)

  • Hakon Hakonarson

    (Center for Applied Genomics, Children's Hospital of Philadelphia
    Perelman School of Medicine, The University of Pennsylvania)

  • Luigi Ferrucci

    (Translational Gerontology Branch, National institute on Aging)

  • Robert A. Scott

    (MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus)

  • Andrew D. Morris

    (Usher Institute for Population Health Sciences and Informatics, University of Edinburgh)

  • Colin N. A. Palmer

    (Centre for Pharmacogenetics and Pharmacogenomics, Medical Research Institute, University of Dundee, Ninewells Hospital and School of Medicine)

  • George Dedoussis

    (Harokopio University of Athens)

  • Panos Deloukas

    (William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London
    Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University)

  • Lars Bertram

    (Vertebrate Genomics, Max Planck Institute for Molecular Genetics
    Faculty of Medicine, Imperial College London, Charing Cross Campus
    Institutes for Neurogenetics and Integrative & Experimental Genomics, University of Lübeck)

  • Ulman Lindenberger

    (Center for Lifespan Psychology, Max Planck Institute for Human Development)

  • Sonja I. Berndt

    (National Cancer Institute, National Institutes of Health)

  • Cecilia M. Lindgren

    (Program in Medical and Population Genetics, Broad Institute
    Wellcome Trust Centre for Human Genetics, University of Oxford)

  • Nicholas J. Timpson

    (MRC Integrative Epidemiology Unit, University of Bristol)

  • Anke Tönjes

    (University of Leipzig)

  • Patricia B. Munroe

    (Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London
    NIHR Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London)

  • Thorkild I. A. Sørensen

    (MRC Integrative Epidemiology Unit, University of Bristol
    Novo Nordisk Centre for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen
    Institute of Preventive Medicine, Bispebjerg and Frederiksberg Hospital, The Capital Region)

  • Charles N. Rotimi

    (Center for Research on Genomics and Global Health, National Human Genome Research Institute)

  • Donna K. Arnett

    (University of Alabama at Birmingham)

  • Albertine J. Oldehinkel

    (University Medical Center Groningen, University of Groningen)

  • Sharon L. R. Kardia

    (University of Michigan)

  • Beverley Balkau

    (Epidemiology of diabetes, obesity and chronic kidney disease over the lifecourse, Inserm, CESP Center for Research in Epidemiology and Population Health U1018)

  • Giovanni Gambaro

    (Catholic University of the Sacred Heart)

  • Andrew P. Morris

    (Estonian Genome Center, University of Tartu
    Wellcome Trust Centre for Human Genetics, University of Oxford
    University of Liverpool)

  • Johan G. Eriksson

    (National Institute for Health and Welfare
    University of Helsinki
    Vasa Central Hospital
    Folkhälsan Reasearch Centre, PB 63, University of Helsinki)

  • Margie J. Wright

    (Neuro-Imaging Genetics, QIMR Berghofer Medical Research Institute)

  • Nicholas G. Martin

    (Genetic Epidemiology, QIMR Berghofer Medical Research Institute)

  • Steven C. Hunt

    (University of Utah)

  • John M. Starr

    (Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh
    Alzheimer Scotland Research Centre, University of Edinburgh)

  • Ian J. Deary

    (Psychology, University of Edinburgh
    Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh)

  • Lyn R. Griffiths

    (Institute of Health and Biomedical Innovation, Queensland University of Technology)

  • Henning Tiemeier

    (Erasmus Medical Center
    Erasmus Medical Center)

  • Nicola Pirastu

    (University of Trieste
    Institute for Maternal and Child Health - IRCCS “Burlo Garofolo”)

  • Jaakko Kaprio

    (Institute for Molecular Medicine Finland (FIMM), University of Helsinki
    University of Helsinki, Hjelt Institute
    National Institute for Health and Welfare (THL))

  • Nicholas J. Wareham

    (MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus)

  • Louis Pérusse

    (Laval University)

  • James G. Wilson

    (University of Mississippi Medical Center)

  • Giorgia Girotto

    (University of Trieste)

  • Mark J. Caulfield

    (Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London
    NIHR Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London)

  • Olli Raitakari

    (University of Turku and Turku University Hospital
    Research Center of Applied and Preventive Cardiovascular medicine, University of Turku)

  • Dorret I. Boomsma

    (VU University Amsterdam)

  • Christian Gieger

    (Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
    Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health
    Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health)

  • Pim van der Harst

    (University of Groningen, University Medical Center Groningen
    Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute
    University of Groningen, University Medical Center Groningen)

  • Andrew A. Hicks

    (Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), 39100 Bolzano, Italy (affiliated Institute of the University of Lübeck, D-23562 Lübeck, Germany).)

  • Peter Kraft

    (Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health)

  • Juha Sinisalo

    (HUCH Heart and Lung center, Helsinki University Central Hospital)

  • Paul Knekt

    (Functional Capacity and Welfare, National Institute for Health and Welfare)

  • Magnus Johannesson

    (Stockholm School of Economics)

  • Patrik K. E. Magnusson

    (Karolinska Institutet)

  • Anders Hamsten

    (Atherosclerosis Research Unit, Karolinska Institutet)

  • Reinhold Schmidt

    (Medical University Graz)

  • Ingrid B. Borecki

    (Washington University School of Medicine)

  • Erkki Vartiainen

    (National Institute for Health and Welfare)

  • Diane M. Becker

    (The GeneSTAR Research Program, The Johns Hopkins University School of Medicine
    Johns Hopkins Bloomberg School of Public Health)

  • Dwaipayan Bharadwaj

    (Genomics and Molecular Medicine, CSIR-Institute of Genomics & Integrative Biology
    School of Biotechnology, Jawaharlal Nehru University)

  • Karen L. Mohlke

    (University of North Carolina)

  • Michael Boehnke

    (University of Michigan)

  • Cornelia M. van Duijn

    (Erasmus Medical Center)

  • Dharambir K. Sanghera

    (University of Oklahoma Health Sciences Center
    University of Oklahoma Health Sciences Center)

  • Alexander Teumer

    (Institute for Community Medicine, University Medicine Greifswald)

  • Eleftheria Zeggini

    (Human Genetics, Wellcome Trust Sanger Institute, Hinxton)

  • Andres Metspalu

    (Estonian Genome Center, University of Tartu
    Institute of Molecular and Cell Biology, University of Tartu)

  • Paolo Gasparini

    (Institute for Maternal and Child Health - IRCCS “Burlo Garofolo”
    Sidra Medical and Research Centre)

  • Sheila Ulivi

    (Institute for Maternal and Child Health - IRCCS “Burlo Garofolo”)

  • Carole Ober

    (University of Chicago)

  • Daniela Toniolo

    (San Raffaele Scientific Institute)

  • Igor Rudan

    (Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh)

  • David J. Porteous

    (Centre for Genomic and Experimental Medicine, University of Edinburgh
    Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh)

  • Marina Ciullo

    (Institute of Genetics and Biophysics “A. Buzzati-Traverso” CNR)

  • Tim D. Spector

    (King's College London)

  • Caroline Hayward

    (MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh)

  • Josée Dupuis

    (Boston University School of Public Health
    National Heart, Lung, and Blood Institute's Framingham Heart Study)

  • Ruth J. F. Loos

    (The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai
    The Genetics of Obesity and Related Metabolic Traits Program, Icahn School of Medicine at Mount Sinai
    The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place)

  • Alan F. Wright

    (MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh)

  • Giriraj R. Chandak

    (Genomic Research on Complex Diseases (GRC) Group, CSIR-Centre for Cellular and Molecular Biology, Habshiguda
    Genome Institute of Singapore)

  • Peter Vollenweider

    (University Hospital)

  • Alan R. Shuldiner

    (Diabetes, and Nutrition and Program for Personalised and Genomic Medicine, University of Maryland School of Medicine
    Program for Personalised and Genomic Medicine, University of Maryland School of Medicine
    Geriatric Research and Education Clinical Center, Veterans Administration Medical Center)

  • Paul M. Ridker

    (Brigham and Women's Hospital)

  • Jerome I. Rotter

    (Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute
    Harbor-UCLA Medical Center)

  • Naveed Sattar

    (BHF Glasgow Cardiovascular Research Centre, University of Glasgow)

  • Ulf Gyllensten

    (Genetics, and Pathology, Biomedical Center, SciLifeLab Uppsala, Uppsala University)

  • Kari E. North

    (Epidemiology, University of North Carolina
    Carolina Center for Genome Sciences, University of North Carolina at Chapel Hill)

  • Mario Pirastu

    (Institute of Population Genetics, National Research Council)

  • Bruce M. Psaty

    (Cardiovascular Health Research Unit, Epidemiology and Health Services, University of Washington
    Group Health Research Institute, Group Health Cooperative)

  • David R. Weir

    (Institute for Social Research, University of Michigan)

  • Markku Laakso

    (University of Eastern Finland and Kuopio University Hospital)

  • Vilmundur Gudnason

    (Icelandic Heart Association
    Faculty of Medicine, University of Iceland)

  • Atsushi Takahashi

    (Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences)

  • John C. Chambers

    (Imperial College London
    Ealing Hospital NHS Trust
    Imperial College Healthcare NHS Trust, Imperial College London)

  • Jaspal S. Kooner

    (Ealing Hospital NHS Trust
    National Heart and Lung Institute, Imperial College London
    Imperial College Healthcare NHS Trust, Imperial College London)

  • David P. Strachan

    (Population Health Research Institute, St George's, University of London, Cranmer Terrace)

  • Harry Campbell

    (Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh)

  • Joel N. Hirschhorn

    (Boston Children's Hospital
    Program in Medical and Population Genetics, Broad Institute
    Harvard Medical School)

  • Markus Perola

    (Estonian Genome Center, University of Tartu
    Unit of Public Health Genomics, National Institute for Health and Welfare)

  • Ozren Polašek

    (Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh
    School of Medicine, University of Split)

  • James F. Wilson

    (Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh
    MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh)

Abstract

An analysis of 16 health-related quantitative traits in approximately 350,000 individuals reveals statistically significant associations between genome-wide homozygosity and four complex traits (height, lung function, cognitive ability and educational attainment); in each case increased homozygosity associates with a decreased trait value, but no evidence was seen of an influence on blood pressure, cholesterol, or ten other cardio-metabolic traits.

Suggested Citation

  • Peter K. Joshi & Tonu Esko & Hannele Mattsson & Niina Eklund & Ilaria Gandin & Teresa Nutile & Anne U. Jackson & Claudia Schurmann & Albert V. Smith & Weihua Zhang & Yukinori Okada & Alena Stančáková , 2015. "Directional dominance on stature and cognition in diverse human populations," Nature, Nature, vol. 523(7561), pages 459-462, July.
    • Handle: RePEc:nat:nature:v:523:y:2015:i:7561:d:10.1038_nature14618
    DOI: 10.1038/nature14618
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    1. Elena Arciero & Sufyan A. Dogra & Daniel S. Malawsky & Massimo Mezzavilla & Theofanis Tsismentzoglou & Qin Qin Huang & Karen A. Hunt & Dan Mason & Saghira Malik Sharif & David A. Heel & Eamonn Sherida, 2021. "Fine-scale population structure and demographic history of British Pakistanis," Nature Communications, Nature, vol. 12(1), pages 1-16, December.

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