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Network evolution hinges on history

Author

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  • Aaron M. New

    (Aaron M. New and Ben Lehner are at the EMBL-CRG Systems Biology Unit, Centre for Genomic Regulation (CRG), 08003 Barcelona, and at the Universitat Pompeu Fabra, Barcelona, Spain.)

  • Ben Lehner

    (Aaron M. New and Ben Lehner are at the EMBL-CRG Systems Biology Unit, Centre for Genomic Regulation (CRG), 08003 Barcelona, and at the Universitat Pompeu Fabra, Barcelona, Spain.
    B.L. is also at the Institució Catalana de Recerca i Estudis Avançats, Barcelona.)

Abstract

The effects of mutations in proteins can depend on the occurrence of previous mutations. It emerges that such historical contingency is also important during the evolution of gene regulatory networks. See Letter p.361

Suggested Citation

  • Aaron M. New & Ben Lehner, 2015. "Network evolution hinges on history," Nature, Nature, vol. 523(7560), pages 297-298, July.
    • Handle: RePEc:nat:nature:v:523:y:2015:i:7560:d:10.1038_nature14537
    DOI: 10.1038/nature14537
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