IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v522y2015i7557d10.1038_nature14326.html
   My bibliography  Save this article

PPAR-α and glucocorticoid receptor synergize to promote erythroid progenitor self-renewal

Author

Listed:
  • Hsiang-Ying Lee

    (Whitehead Institute for Biomedical Research, Nine Cambridge Center)

  • Xiaofei Gao

    (Whitehead Institute for Biomedical Research, Nine Cambridge Center)

  • M. Inmaculada Barrasa

    (Whitehead Institute for Biomedical Research, Nine Cambridge Center)

  • Hu Li

    (Center for Individualized Medicine, Mayo Clinic)

  • Russell R. Elmes

    (Whitehead Institute for Biomedical Research, Nine Cambridge Center)

  • Luanne L. Peters

    (The Jackson Laboratory)

  • Harvey F. Lodish

    (Whitehead Institute for Biomedical Research, Nine Cambridge Center
    Massachusetts Institute of Technology)

Abstract

Some types of anaemia do not respond to erythropoietin (Epo) treatment because patients do not have sufficient numbers of Epo-sensitive erythroid precursor cells; here, two agonists of PPAR-α are found to synergize with glucocorticoid treatment to promote early erythroid progenitor self-renewal, increasing the production of mature red blood cells in both human and mouse cultures and alleviating anaemia in mouse models.

Suggested Citation

  • Hsiang-Ying Lee & Xiaofei Gao & M. Inmaculada Barrasa & Hu Li & Russell R. Elmes & Luanne L. Peters & Harvey F. Lodish, 2015. "PPAR-α and glucocorticoid receptor synergize to promote erythroid progenitor self-renewal," Nature, Nature, vol. 522(7557), pages 474-477, June.
    • Handle: RePEc:nat:nature:v:522:y:2015:i:7557:d:10.1038_nature14326
    DOI: 10.1038/nature14326
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature14326
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature14326?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:522:y:2015:i:7557:d:10.1038_nature14326. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.