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Pioneer factors govern super-enhancer dynamics in stem cell plasticity and lineage choice

Author

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  • Rene C. Adam

    (Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology & Development, The Rockefeller University)

  • Hanseul Yang

    (Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology & Development, The Rockefeller University)

  • Shira Rockowitz

    (Albert Einstein College of Medicine)

  • Samantha B. Larsen

    (Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology & Development, The Rockefeller University)

  • Maria Nikolova

    (Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology & Development, The Rockefeller University)

  • Daniel S. Oristian

    (Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology & Development, The Rockefeller University)

  • Lisa Polak

    (Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology & Development, The Rockefeller University)

  • Meelis Kadaja

    (Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology & Development, The Rockefeller University)

  • Amma Asare

    (Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology & Development, The Rockefeller University)

  • Deyou Zheng

    (Albert Einstein College of Medicine
    Albert Einstein College of Medicine)

  • Elaine Fuchs

    (Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology & Development, The Rockefeller University)

Abstract

An analysis of mouse skin reveals that super-enhancers are critical to identity, lineage commitment and plasticity of adult stem cells; dynamic super-enhancer remodelling in new niches is dependent on the levels of pioneer transcription factor SOX9, which is identified as a key regulator of super-enhancer chromatin for hair follicle stem cells.

Suggested Citation

  • Rene C. Adam & Hanseul Yang & Shira Rockowitz & Samantha B. Larsen & Maria Nikolova & Daniel S. Oristian & Lisa Polak & Meelis Kadaja & Amma Asare & Deyou Zheng & Elaine Fuchs, 2015. "Pioneer factors govern super-enhancer dynamics in stem cell plasticity and lineage choice," Nature, Nature, vol. 521(7552), pages 366-370, May.
    • Handle: RePEc:nat:nature:v:521:y:2015:i:7552:d:10.1038_nature14289
    DOI: 10.1038/nature14289
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    Cited by:

    1. Miwa Tanaka & Surachada Chuaychob & Mizuki Homme & Yukari Yamazaki & Ruyin Lyu & Kyoko Yamashita & Keisuke Ae & Seiichi Matsumoto & Kohei Kumegawa & Reo Maruyama & Wei Qu & Yohei Miyagi & Ryuji Yokoka, 2023. "ASPSCR1::TFE3 orchestrates the angiogenic program of alveolar soft part sarcoma," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    2. Ines Sturmlechner & Chance C. Sine & Karthik B. Jeganathan & Cheng Zhang & Raul O. Fierro Velasco & Darren J. Baker & Hu Li & Jan M. Deursen, 2022. "Senescent cells limit p53 activity via multiple mechanisms to remain viable," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    3. Sandra Kessler & Maryline Minoux & Onkar Joshi & Yousra Zouari & Sebastien Ducret & Fiona Ross & Nathalie Vilain & Adwait Salvi & Joachim Wolff & Hubertus Kohler & Michael B. Stadler & Filippo M. Rijl, 2023. "A multiple super-enhancer region establishes inter-TAD interactions and controls Hoxa function in cranial neural crest," Nature Communications, Nature, vol. 14(1), pages 1-22, December.
    4. Pedro Madrigal & Siwei Deng & Yuliang Feng & Stefania Militi & Kim Jee Goh & Reshma Nibhani & Rodrigo Grandy & Anna Osnato & Daniel Ortmann & Stephanie Brown & Siim Pauklin, 2023. "Epigenetic and transcriptional regulations prime cell fate before division during human pluripotent stem cell differentiation," Nature Communications, Nature, vol. 14(1), pages 1-23, December.
    5. Andreas Lackner & Michael Müller & Magdalena Gamperl & Delyana Stoeva & Olivia Langmann & Henrieta Papuchova & Elisabeth Roitinger & Gerhard Dürnberger & Richard Imre & Karl Mechtler & Paulina A. Lato, 2023. "The Fgf/Erf/NCoR1/2 repressive axis controls trophoblast cell fate," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    6. Mingsen Li & Huaxing Huang & Bofeng Wang & Shaoshuai Jiang & Huizhen Guo & Liqiong Zhu & Siqi Wu & Jiafeng Liu & Li Wang & Xihong Lan & Wang Zhang & Jin Zhu & Fuxi Li & Jieying Tan & Zhen Mao & Chunqi, 2022. "Comprehensive 3D epigenomic maps define limbal stem/progenitor cell function and identity," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

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