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An epigenome-wide association study of total serum immunoglobulin E concentration

Author

Listed:
  • Liming Liang

    (Harvard School of Public Health)

  • Saffron A. G. Willis-Owen

    (National Heart and Lung Institute, Imperial College, London SW3 6LY, UK)

  • Catherine Laprise

    (Université du Québec à Chicoutimi, Saguenay, Québec G7H 2B1, Canada)

  • Kenny C. C. Wong

    (National Heart and Lung Institute, Imperial College, London SW3 6LY, UK)

  • Gwyneth A. Davies

    (Institute of Life Science, College of Medicine, Swansea University, Swansea SA2 8PP, UK)

  • Thomas J. Hudson

    (Ontario Institute for Cancer Research, Toronto, Ontario M5G 0A3, Canada
    University of Toronto, Ontario M5S 1A1, Canada)

  • Aristea Binia

    (National Heart and Lung Institute, Imperial College, London SW3 6LY, UK)

  • Julian M. Hopkin

    (Institute of Life Science, College of Medicine, Swansea University, Swansea SA2 8PP, UK)

  • Ivana V. Yang

    (University of Colorado School of Medicine and National Jewish Health)

  • Elin Grundberg

    (McGill University and Génome Québec Innovation Centre, Montréal H3A 1B1, Canada)

  • Stephan Busche

    (McGill University and Génome Québec Innovation Centre, Montréal H3A 1B1, Canada)

  • Marie Hudson

    (Jewish General Hospital and Lady Davis Research Institute, Montréal H3T 1E2, Canada)

  • Lars Rönnblom

    (SciLifeLab, Uppsala University, Uppsala SE-751 44, Sweden)

  • Tomi M. Pastinen

    (McGill University and Génome Québec Innovation Centre, Montréal H3A 1B1, Canada
    McGill University Health Centre, Montréal H3H 1P3, Canada)

  • David A. Schwartz

    (University of Colorado School of Medicine and National Jewish Health)

  • G. Mark Lathrop

    (McGill University and Génome Québec Innovation Centre, Montréal H3A 1B1, Canada)

  • Miriam F. Moffatt

    (National Heart and Lung Institute, Imperial College, London SW3 6LY, UK)

  • William O. C. M. Cookson

    (National Heart and Lung Institute, Imperial College, London SW3 6LY, UK)

Abstract

A survey of epigenetic associations between serum immunoglobulin E concentrations indicating allergy and methylation at CpG islands in families and a population sample has revealed associations at 36 loci that harbour genes encoding proteins including eosinophil products and phospholipid inflammatory mediators.

Suggested Citation

  • Liming Liang & Saffron A. G. Willis-Owen & Catherine Laprise & Kenny C. C. Wong & Gwyneth A. Davies & Thomas J. Hudson & Aristea Binia & Julian M. Hopkin & Ivana V. Yang & Elin Grundberg & Stephan Bus, 2015. "An epigenome-wide association study of total serum immunoglobulin E concentration," Nature, Nature, vol. 520(7549), pages 670-674, April.
    • Handle: RePEc:nat:nature:v:520:y:2015:i:7549:d:10.1038_nature14125
    DOI: 10.1038/nature14125
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