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Phosphodiesterase 9A controls nitric-oxide-independent cGMP and hypertrophic heart disease

Author

Listed:
  • Dong I. Lee

    (The Johns Hopkins Medical Institutions)

  • Guangshuo Zhu

    (The Johns Hopkins Medical Institutions)

  • Takashi Sasaki

    (Advanced Medical Research Laboratories, Mitsubishi Tanabe Pharma Corporation, Yokohama, Kanagawa 227-0033, Japan)

  • Gun-Sik Cho

    (The Johns Hopkins Medical Institutions)

  • Nazha Hamdani

    (Institute for Cardiovascular Research, VU University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands)

  • Ronald Holewinski

    (The Johns Hopkins Medical Institutions
    Heart Institute and Advanced Clinical Biosystems Research Institute, Cedar Sinai Medical Center, 8700 Beverly Blvd, AHSP A9229 Los Angeles, California 90048, USA)

  • Su-Hyun Jo

    (Institute of Bioscience and Biotechnology, BK21 plus Graduate Program, Kangwon National University College of Medicine)

  • Thomas Danner

    (The Johns Hopkins Medical Institutions)

  • Manling Zhang

    (The Johns Hopkins Medical Institutions)

  • Peter P. Rainer

    (The Johns Hopkins Medical Institutions)

  • Djahida Bedja

    (The Johns Hopkins Medical Institutions)

  • Jonathan A. Kirk

    (The Johns Hopkins Medical Institutions)

  • Mark J. Ranek

    (The Johns Hopkins Medical Institutions)

  • Wolfgang R. Dostmann

    (University of Vermont)

  • Chulan Kwon

    (The Johns Hopkins Medical Institutions)

  • Kenneth B. Margulies

    (Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania)

  • Jennifer E. Van Eyk

    (The Johns Hopkins Medical Institutions
    Heart Institute and Advanced Clinical Biosystems Research Institute, Cedar Sinai Medical Center, 8700 Beverly Blvd, AHSP A9229 Los Angeles, California 90048, USA)

  • Walter J. Paulus

    (Institute for Cardiovascular Research, VU University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands)

  • Eiki Takimoto

    (The Johns Hopkins Medical Institutions)

  • David A. Kass

    (The Johns Hopkins Medical Institutions)

Abstract

The inhibition, in mice, of the phosphodiesterase PDE9A, which specifically regulates natriuretic-peptide-coupled cGMP signalling, is independent of nitric oxide and is upregulated in failing human hearts, and can reverse pre-established stress-induced heart disease.

Suggested Citation

  • Dong I. Lee & Guangshuo Zhu & Takashi Sasaki & Gun-Sik Cho & Nazha Hamdani & Ronald Holewinski & Su-Hyun Jo & Thomas Danner & Manling Zhang & Peter P. Rainer & Djahida Bedja & Jonathan A. Kirk & Mark , 2015. "Phosphodiesterase 9A controls nitric-oxide-independent cGMP and hypertrophic heart disease," Nature, Nature, vol. 519(7544), pages 472-476, March.
    • Handle: RePEc:nat:nature:v:519:y:2015:i:7544:d:10.1038_nature14332
    DOI: 10.1038/nature14332
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