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Conserved epigenomic signals in mice and humans reveal immune basis of Alzheimer’s disease

Author

Listed:
  • Elizabeta Gjoneska

    (The Picower Institute for Learning and Memory, Massachusetts Institute of Technology
    Broad Institute of Harvard University and Massachusetts Institute of Technology)

  • Andreas R. Pfenning

    (Broad Institute of Harvard University and Massachusetts Institute of Technology
    Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology)

  • Hansruedi Mathys

    (The Picower Institute for Learning and Memory, Massachusetts Institute of Technology)

  • Gerald Quon

    (Broad Institute of Harvard University and Massachusetts Institute of Technology
    Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology)

  • Anshul Kundaje

    (Broad Institute of Harvard University and Massachusetts Institute of Technology
    Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology
    Stanford University)

  • Li-Huei Tsai

    (The Picower Institute for Learning and Memory, Massachusetts Institute of Technology
    Broad Institute of Harvard University and Massachusetts Institute of Technology)

  • Manolis Kellis

    (Broad Institute of Harvard University and Massachusetts Institute of Technology
    Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology)

Abstract

Analysis of transcriptional and epigenomic changes in the hippocampus of a mouse model of Alzheimer’s disease shows that immune function genes and regulatory regions are upregulated, whereas genes and regulatory regions involved in synaptic plasticity, learning and memory are downregulated; genetic variants associated with Alzheimer’s disease are only enriched in orthologues of upregulated immune regions, suggesting that dysregulation of immune processes may underlie Alzheimer’s disease predisposition.

Suggested Citation

  • Elizabeta Gjoneska & Andreas R. Pfenning & Hansruedi Mathys & Gerald Quon & Anshul Kundaje & Li-Huei Tsai & Manolis Kellis, 2015. "Conserved epigenomic signals in mice and humans reveal immune basis of Alzheimer’s disease," Nature, Nature, vol. 518(7539), pages 365-369, February.
    • Handle: RePEc:nat:nature:v:518:y:2015:i:7539:d:10.1038_nature14252
    DOI: 10.1038/nature14252
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    Cited by:

    1. Liang-Yu Fu & Tao Zhu & Xinkai Zhou & Ranran Yu & Zhaohui He & Peijing Zhang & Zhigui Wu & Ming Chen & Kerstin Kaufmann & Dijun Chen, 2022. "ChIP-Hub provides an integrative platform for exploring plant regulome," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

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