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Modulation of the proteoglycan receptor PTPσ promotes recovery after spinal cord injury

Author

Listed:
  • Bradley T. Lang

    (Case Western Reserve University School of Medicine)

  • Jared M. Cregg

    (Case Western Reserve University School of Medicine)

  • Marc A. DePaul

    (Case Western Reserve University School of Medicine)

  • Amanda P. Tran

    (Case Western Reserve University School of Medicine)

  • Kui Xu

    (Center for Brain and Spinal Cord Repair, Wexner Medical Center at The Ohio State University)

  • Scott M. Dyck

    (University of Manitoba, Winnipeg, Manitoba R3E 0J9, Canada)

  • Kathryn M. Madalena

    (Case Western Reserve University School of Medicine)

  • Benjamin P. Brown

    (Baldwin Wallace University)

  • Yi-Lan Weng

    (Institute for Cell Engineering, Johns Hopkins University School of Medicine)

  • Shuxin Li

    (Shriners Hospital’s Pediatric Research Center (Center for Neural Repair and Rehabilitation), Temple University School of Medicine)

  • Soheila Karimi-Abdolrezaee

    (University of Manitoba, Winnipeg, Manitoba R3E 0J9, Canada)

  • Sarah A. Busch

    (Case Western Reserve University School of Medicine)

  • Yingjie Shen

    (Center for Brain and Spinal Cord Repair, Wexner Medical Center at The Ohio State University)

  • Jerry Silver

    (Case Western Reserve University School of Medicine)

Abstract

Regeneration and plasticity after spinal cord injury are limited by inhibitory proteoglycans; here, modulation of a receptor for proteoglycans in rats is shown to lead to functional recovery after injury.

Suggested Citation

  • Bradley T. Lang & Jared M. Cregg & Marc A. DePaul & Amanda P. Tran & Kui Xu & Scott M. Dyck & Kathryn M. Madalena & Benjamin P. Brown & Yi-Lan Weng & Shuxin Li & Soheila Karimi-Abdolrezaee & Sarah A. , 2015. "Modulation of the proteoglycan receptor PTPσ promotes recovery after spinal cord injury," Nature, Nature, vol. 518(7539), pages 404-408, February.
    • Handle: RePEc:nat:nature:v:518:y:2015:i:7539:d:10.1038_nature13974
    DOI: 10.1038/nature13974
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    Cited by:

    1. Chikako Nakajima & Masato Sawada & Erika Umeda & Yuma Takagi & Norihiko Nakashima & Kazuya Kuboyama & Naoko Kaneko & Satoaki Yamamoto & Haruno Nakamura & Naoki Shimada & Koichiro Nakamura & Kumiko Mat, 2024. "Identification of the growth cone as a probe and driver of neuronal migration in the injured brain," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    2. Isaac Francos-Quijorna & Marina Sánchez-Petidier & Emily R. Burnside & Smaranda R. Badea & Abel Torres-Espin & Lucy Marshall & Fred Winter & Joost Verhaagen & Victoria Moreno-Manzano & Elizabeth J. Br, 2022. "Chondroitin sulfate proteoglycans prevent immune cell phenotypic conversion and inflammation resolution via TLR4 in rodent models of spinal cord injury," Nature Communications, Nature, vol. 13(1), pages 1-23, December.

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