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Interception of host angiogenic signalling limits mycobacterial growth

Author

Listed:
  • Stefan H. Oehlers

    (Center for Microbial Pathogenesis, Duke University Medical Center)

  • Mark R. Cronan

    (Center for Microbial Pathogenesis, Duke University Medical Center)

  • Ninecia R. Scott

    (Center for Microbial Pathogenesis, Duke University Medical Center)

  • Monica I. Thomas

    (Center for Microbial Pathogenesis, Duke University Medical Center)

  • Kazuhide S. Okuda

    (The University of Auckland, Auckland 1023, New Zealand)

  • Eric M. Walton

    (Center for Microbial Pathogenesis, Duke University Medical Center)

  • Rebecca W. Beerman

    (Center for Microbial Pathogenesis, Duke University Medical Center)

  • Philip S. Crosier

    (The University of Auckland, Auckland 1023, New Zealand)

  • David M. Tobin

    (Center for Microbial Pathogenesis, Duke University Medical Center)

Abstract

Using a model of tuberculosis in zebrafish, granuloma formation is shown to coincide with hypoxia and angiogenesis; furthermore, the pharmacological inhibition of the pro-angiogenic VEGF pathway reduces infection burden, suggesting a possible treatment strategy in patients with the disease.

Suggested Citation

  • Stefan H. Oehlers & Mark R. Cronan & Ninecia R. Scott & Monica I. Thomas & Kazuhide S. Okuda & Eric M. Walton & Rebecca W. Beerman & Philip S. Crosier & David M. Tobin, 2015. "Interception of host angiogenic signalling limits mycobacterial growth," Nature, Nature, vol. 517(7536), pages 612-615, January.
    • Handle: RePEc:nat:nature:v:517:y:2015:i:7536:d:10.1038_nature13967
    DOI: 10.1038/nature13967
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    Cited by:

    1. Julia Y. Kam & Elinor Hortle & Elizabeth Krogman & Sherridan E. Warner & Kathryn Wright & Kaiming Luo & Tina Cheng & Pradeep Manuneedhi Cholan & Kazu Kikuchi & James A. Triccas & Warwick J. Britton & , 2022. "Rough and smooth variants of Mycobacterium abscessus are differentially controlled by host immunity during chronic infection of adult zebrafish," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    2. Videlis Nduba & Lilian N. Njagi & Wilfred Murithi & Zipporah Mwongera & Jodi Byers & Gisella Logioia & Glenna Peterson & R. Max Segnitz & Kevin Fennelly & Thomas R. Hawn & David J. Horne, 2024. "Mycobacterium tuberculosis cough aerosol culture status associates with host characteristics and inflammatory profiles," Nature Communications, Nature, vol. 15(1), pages 1-15, December.

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