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Adenosine activates brown adipose tissue and recruits beige adipocytes via A2A receptors

Author

Listed:
  • Thorsten Gnad

    (Institute of Pharmacology and Toxicology, University Hospital, University of Bonn, 53127 Bonn, Germany)

  • Saskia Scheibler

    (Institute of Pharmacology and Toxicology, University Hospital, University of Bonn, 53127 Bonn, Germany
    Research Training Group 1873, University of Bonn, 53127 Bonn, Germany)

  • Ivar von Kügelgen

    (Institute of Pharmacology and Toxicology, University Hospital, University of Bonn, 53127 Bonn, Germany)

  • Camilla Scheele

    (The Centre of Inflammation and Metabolism and the Centre for Physical Activity Research, Rigshospitalet, 2100 Copenhagen, Denmark)

  • Ana Kilić

    (Institute of Pharmacology and Toxicology, University Hospital, University of Bonn, 53127 Bonn, Germany)

  • Anja Glöde

    (Institute of Pharmacology and Toxicology, University Hospital, University of Bonn, 53127 Bonn, Germany)

  • Linda S. Hoffmann

    (Institute of Pharmacology and Toxicology, University Hospital, University of Bonn, 53127 Bonn, Germany)

  • Laia Reverte-Salisa

    (Institute of Pharmacology and Toxicology, University Hospital, University of Bonn, 53127 Bonn, Germany
    Research Training Group 1873, University of Bonn, 53127 Bonn, Germany)

  • Philipp Horn

    (Institute of Pharmacology and Toxicology, University Hospital, University of Bonn, 53127 Bonn, Germany)

  • Samet Mutlu

    (Institute of Pharmacology and Toxicology, University Hospital, University of Bonn, 53127 Bonn, Germany)

  • Ali El-Tayeb

    (Pharmaceutical Institute, Pharmaceutical Chemistry I, University of Bonn, 53121 Bonn, Germany)

  • Mathias Kranz

    (Helmholtz-Zentrum Dresden - Rossendorf, Institute of Radiopharmaceutical Cancer Research, Research Site Leipzig, 04318 Leipzig, Germany)

  • Winnie Deuther-Conrad

    (Helmholtz-Zentrum Dresden - Rossendorf, Institute of Radiopharmaceutical Cancer Research, Research Site Leipzig, 04318 Leipzig, Germany)

  • Peter Brust

    (Helmholtz-Zentrum Dresden - Rossendorf, Institute of Radiopharmaceutical Cancer Research, Research Site Leipzig, 04318 Leipzig, Germany)

  • Martin E. Lidell

    (Institute of Biomedicine, The Sahlgrenska Academy, University of Gothenburg, 413 90 Gothenburg, Sweden)

  • Matthias J. Betz

    (Institute of Biomedicine, The Sahlgrenska Academy, University of Gothenburg, 413 90 Gothenburg, Sweden)

  • Sven Enerbäck

    (Institute of Biomedicine, The Sahlgrenska Academy, University of Gothenburg, 413 90 Gothenburg, Sweden)

  • Jürgen Schrader

    (University of Düsseldorf, 40225 Düsseldorf, Germany)

  • Gennady G. Yegutkin

    (Medicity Research Laboratory, University of Turku, 20520 Turku, Finland)

  • Christa E. Müller

    (Pharmaceutical Institute, Pharmaceutical Chemistry I, University of Bonn, 53121 Bonn, Germany
    Pharma Center, University of Bonn, 53127 Bonn, Germany)

  • Alexander Pfeifer

    (Institute of Pharmacology and Toxicology, University Hospital, University of Bonn, 53127 Bonn, Germany
    Pharma Center, University of Bonn, 53127 Bonn, Germany)

Abstract

Cold exposure activates brown adipose tissue (BAT) through the sympathetic nervous system, and previous studies have reported inhibitory effects of the purinergic transmitter adenosine in BAT from hamster or rat; here adenosine/A2A signalling is shown to be involved in sympathetic activation of human and murine brown adipocytes to allow protection of mice from diet-induced obesity.

Suggested Citation

  • Thorsten Gnad & Saskia Scheibler & Ivar von Kügelgen & Camilla Scheele & Ana Kilić & Anja Glöde & Linda S. Hoffmann & Laia Reverte-Salisa & Philipp Horn & Samet Mutlu & Ali El-Tayeb & Mathias Kranz & , 2014. "Adenosine activates brown adipose tissue and recruits beige adipocytes via A2A receptors," Nature, Nature, vol. 516(7531), pages 395-399, December.
    • Handle: RePEc:nat:nature:v:516:y:2014:i:7531:d:10.1038_nature13816
    DOI: 10.1038/nature13816
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