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Loss of signalling via Gα13 in germinal centre B-cell-derived lymphoma

Author

Listed:
  • Jagan R. Muppidi

    (University of California
    University of California
    Howard Hughes Medical Institute, University of California)

  • Roland Schmitz

    (Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health)

  • Jesse A. Green

    (University of California
    Howard Hughes Medical Institute, University of California
    Present address: Immunology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA.)

  • Wenming Xiao

    (Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health)

  • Adrien B. Larsen

    (Beckman Research Institute of the City of Hope)

  • Sterling E. Braun

    (University of California
    Howard Hughes Medical Institute, University of California)

  • Jinping An

    (University of California
    Howard Hughes Medical Institute, University of California)

  • Ying Xu

    (University of California
    Howard Hughes Medical Institute, University of California)

  • Andreas Rosenwald

    (University of Würzburg, 97080 Würzburg, Germany)

  • German Ott

    (Robert-Bosch-Krankenhaus, Auerbachstraße 110, 70376 Stuttgart, Germany
    Dr. Margarete Fischer-Bosch Institute for Clinical Pharmacology, 70376 Stuttgart, Germany)

  • Randy D. Gascoyne

    (British Columbia Cancer Agency, Vancouver, British Columbia V5Z 1L3, Canada)

  • Lisa M. Rimsza

    (University of Arizona)

  • Elias Campo

    (Hospital Clinic, University of Barcelona, 08036 Barcelona, Spain)

  • Elaine S. Jaffe

    (Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health)

  • Jan Delabie

    (Pathology Clinic, Rikshospitalet University Hospital, 0372 Oslo, Norway)

  • Erlend B. Smeland

    (Institute for Cancer Research, Rikshospitalet University Hospital, University of Oslo, 0310 Oslo, Norway
    Center for Cancer Biomedicine, University of Oslo, 0310 Oslo, Norway)

  • Rita M. Braziel

    (Oregon Health and Science University)

  • Raymond R. Tubbs

    (Cleveland Clinic Pathology and Laboratory Medicine Institute)

  • J. R. Cook

    (Cleveland Clinic Pathology and Laboratory Medicine Institute)

  • Dennis D. Weisenburger

    (City of Hope National Medical Center)

  • Wing C. Chan

    (University of Nebraska Medical Center
    University of Nebraska Medical Center)

  • Nagarajan Vaidehi

    (Beckman Research Institute of the City of Hope)

  • Louis M. Staudt

    (Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health)

  • Jason G. Cyster

    (University of California
    Howard Hughes Medical Institute, University of California)

Abstract

Inactivation of the S1PR2–Gα13–ARHGEF1 signalling pathway in mice allows Akt activation and promotes dissemination of germinal centre B cells, consistent with a role of function-disrupting mutations in the systemic dissemination of diffuse large B-cell lymphoma.

Suggested Citation

  • Jagan R. Muppidi & Roland Schmitz & Jesse A. Green & Wenming Xiao & Adrien B. Larsen & Sterling E. Braun & Jinping An & Ying Xu & Andreas Rosenwald & German Ott & Randy D. Gascoyne & Lisa M. Rimsza & , 2014. "Loss of signalling via Gα13 in germinal centre B-cell-derived lymphoma," Nature, Nature, vol. 516(7530), pages 254-258, December.
    • Handle: RePEc:nat:nature:v:516:y:2014:i:7530:d:10.1038_nature13765
    DOI: 10.1038/nature13765
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