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Structure of malaria invasion protein RH5 with erythrocyte basigin and blocking antibodies

Author

Listed:
  • Katherine E. Wright

    (University of Oxford, South Parks Road, Oxford OX1 3QU, UK)

  • Kathryn A. Hjerrild

    (Jenner Institute, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ, UK)

  • Jonathan Bartlett

    (University of Oxford, South Parks Road, Oxford OX1 3QU, UK)

  • Alexander D. Douglas

    (Jenner Institute, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ, UK)

  • Jing Jin

    (Jenner Institute, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ, UK)

  • Rebecca E. Brown

    (Jenner Institute, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ, UK)

  • Joseph J. Illingworth

    (Jenner Institute, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ, UK)

  • Rebecca Ashfield

    (Jenner Institute, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ, UK)

  • Stine B. Clemmensen

    (ExpreS2ion Biotechnologies, SCION-DTU Science Park, Agern Allé 1, DK-2970 Horsholm, Denmark)

  • Willem A. de Jongh

    (ExpreS2ion Biotechnologies, SCION-DTU Science Park, Agern Allé 1, DK-2970 Horsholm, Denmark)

  • Simon J. Draper

    (Jenner Institute, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ, UK)

  • Matthew K. Higgins

    (University of Oxford, South Parks Road, Oxford OX1 3QU, UK)

Abstract

Reticulocyte-binding protein homologue 5 (PfRH5) of Plasmodium falciparum, the malaria parasite, is known to be necessary for red blood cell invasion, making PfRH5 a promising vaccine candidate; here the X-ray crystallographic structure of PfRH5 in complex with basigin and with inhibitory antibodies is determined.

Suggested Citation

  • Katherine E. Wright & Kathryn A. Hjerrild & Jonathan Bartlett & Alexander D. Douglas & Jing Jin & Rebecca E. Brown & Joseph J. Illingworth & Rebecca Ashfield & Stine B. Clemmensen & Willem A. de Jongh, 2014. "Structure of malaria invasion protein RH5 with erythrocyte basigin and blocking antibodies," Nature, Nature, vol. 515(7527), pages 427-430, November.
    • Handle: RePEc:nat:nature:v:515:y:2014:i:7527:d:10.1038_nature13715
    DOI: 10.1038/nature13715
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    Cited by:

    1. Tony Triglia & Stephen W. Scally & Benjamin A. Seager & Michał Pasternak & Laura F. Dagley & Alan F. Cowman, 2023. "Plasmepsin X activates the PCRCR complex of Plasmodium falciparum by processing PfRh5 for erythrocyte invasion," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    2. Barnabas G. Williams & Lloyd D. W. King & David Pulido & Doris Quinkert & Amelia M. Lias & Sarah E. Silk & Robert J. Ragotte & Hannah Davies & Jordan R. Barrett & Kirsty McHugh & Cassandra A. Rigby & , 2024. "Development of an improved blood-stage malaria vaccine targeting the essential RH5-CyRPA-RIPR invasion complex," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

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