IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v515y2014i7525d10.1038_nature13601.html
   My bibliography  Save this article

Broad and potent HIV-1 neutralization by a human antibody that binds the gp41–gp120 interface

Author

Listed:
  • Jinghe Huang

    (Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

  • Byong H. Kang

    (Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

  • Marie Pancera

    (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

  • Jeong Hyun Lee

    (The Scripps Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute
    International AIDS Vaccine Initiative (IAVI) Neutralizing Antibody Center, The Scripps Research Institute)

  • Tommy Tong

    (San Diego Biomedical Research Institute)

  • Yu Feng

    (International AIDS Vaccine Initiative (IAVI) Neutralizing Antibody Center, The Scripps Research Institute)

  • Hiromi Imamichi

    (Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

  • Ivelin S. Georgiev

    (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

  • Gwo-Yu Chuang

    (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

  • Aliaksandr Druz

    (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

  • Nicole A. Doria-Rose

    (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

  • Leo Laub

    (Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

  • Kwinten Sliepen

    (Academic Medical Center, University of Amsterdam, Amsterdam 1100 DD, The Netherlands)

  • Marit J. van Gils

    (Academic Medical Center, University of Amsterdam, Amsterdam 1100 DD, The Netherlands)

  • Alba Torrents de la Peña

    (Academic Medical Center, University of Amsterdam, Amsterdam 1100 DD, The Netherlands)

  • Ronald Derking

    (Academic Medical Center, University of Amsterdam, Amsterdam 1100 DD, The Netherlands)

  • Per-Johan Klasse

    (Weill Medical College of Cornell University)

  • Stephen A. Migueles

    (Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

  • Robert T. Bailer

    (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

  • Munir Alam

    (Duke Human Vaccine Institute, Duke University)

  • Pavel Pugach

    (Weill Medical College of Cornell University)

  • Barton F. Haynes

    (Duke Human Vaccine Institute, Duke University)

  • Richard T. Wyatt

    (The Scripps Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute
    International AIDS Vaccine Initiative (IAVI) Neutralizing Antibody Center, The Scripps Research Institute)

  • Rogier W. Sanders

    (Academic Medical Center, University of Amsterdam, Amsterdam 1100 DD, The Netherlands
    Weill Medical College of Cornell University)

  • James M. Binley

    (San Diego Biomedical Research Institute)

  • Andrew B. Ward

    (The Scripps Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute
    International AIDS Vaccine Initiative (IAVI) Neutralizing Antibody Center, The Scripps Research Institute)

  • John R. Mascola

    (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

  • Peter D. Kwong

    (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

  • Mark Connors

    (Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

Abstract

Molecular and structural characterization is reported for a new broad and potent monoclonal antibody against HIV that binds to an epitope bridging the gp41 and gp120 subunits — the antibody affects a step in virus entry after binding to CD4 and before engagement of CCR5.

Suggested Citation

  • Jinghe Huang & Byong H. Kang & Marie Pancera & Jeong Hyun Lee & Tommy Tong & Yu Feng & Hiromi Imamichi & Ivelin S. Georgiev & Gwo-Yu Chuang & Aliaksandr Druz & Nicole A. Doria-Rose & Leo Laub & Kwinte, 2014. "Broad and potent HIV-1 neutralization by a human antibody that binds the gp41–gp120 interface," Nature, Nature, vol. 515(7525), pages 138-142, November.
    • Handle: RePEc:nat:nature:v:515:y:2014:i:7525:d:10.1038_nature13601
    DOI: 10.1038/nature13601
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature13601
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature13601?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Annemart Koornneef & Kanika Vanshylla & Gijs Hardenberg & Lucy Rutten & Nika M. Strokappe & Jeroen Tolboom & Jessica Vreugdenhil & Karin Feddes-de Boer & Aditya Perkasa & Sven Blokland & Judith A. Bur, 2024. "CoPoP liposomes displaying stabilized clade C HIV-1 Env elicit tier 2 multiclade neutralization in rabbits," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    2. Jun Niu & Qi Wang & Wenwen Zhao & Bing Meng & Youwei Xu & Xianfang Zhang & Yi Feng & Qilian Qi & Yanling Hao & Xuan Zhang & Ying Liu & Jiangchao Xiang & Yiming Shao & Bei Yang, 2023. "Structures and immune recognition of Env trimers from two Asia prevalent HIV-1 CRFs," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    3. Yi-Nan Zhang & Jennifer Paynter & Aleksandar Antanasijevic & Joel D. Allen & Mor Eldad & Yi-Zong Lee & Jeffrey Copps & Maddy L. Newby & Linling He & Deborah Chavez & Pat Frost & Anna Goodroe & John Du, 2023. "Single-component multilayered self-assembling protein nanoparticles presenting glycan-trimmed uncleaved prefusion optimized envelope trimers as HIV-1 vaccine candidates," Nature Communications, Nature, vol. 14(1), pages 1-29, December.
    4. Kun-Wei Chan & Christina C. Luo & Hong Lu & Xueling Wu & Xiang-Peng Kong, 2021. "A site of vulnerability at V3 crown defined by HIV-1 bNAb M4008_N1," Nature Communications, Nature, vol. 12(1), pages 1-12, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:515:y:2014:i:7525:d:10.1038_nature13601. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.