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Ultraviolet radiation accelerates BRAF-driven melanomagenesis by targeting TP53

Author

Listed:
  • Amaya Viros

    (Molecular Oncology Group, Cancer Research UK Manchester Institute, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK)

  • Berta Sanchez-Laorden

    (Molecular Oncology Group, Cancer Research UK Manchester Institute, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK)

  • Malin Pedersen

    (Signal Transduction Team, Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK)

  • Simon J. Furney

    (Molecular Oncology Group, Cancer Research UK Manchester Institute, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK)

  • Joel Rae

    (Signal Transduction Team, Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK)

  • Kate Hogan

    (Molecular Oncology Group, Cancer Research UK Manchester Institute, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK)

  • Sarah Ejiama

    (Molecular Oncology Group, Cancer Research UK Manchester Institute, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK)

  • Maria Romina Girotti

    (Molecular Oncology Group, Cancer Research UK Manchester Institute, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK)

  • Martin Cook

    (Molecular Oncology Group, Cancer Research UK Manchester Institute, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK
    Histopathology, Royal Surrey County Hospital, Egerton Road, Guildford GU2 7XX, UK)

  • Nathalie Dhomen

    (Signal Transduction Team, Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK)

  • Richard Marais

    (Molecular Oncology Group, Cancer Research UK Manchester Institute, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK
    Signal Transduction Team, Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK)

Abstract

Exposing mice with the BRAF (V600E) mutation to levels of ultraviolet radiation that mimic mild sunburn in humans is shown to induce mutations in the tumour suppressor Trp53 (TP53 in humans), accelerating the development of melanoma; these results support the use of sunscreen in individuals at risk of this cancer.

Suggested Citation

  • Amaya Viros & Berta Sanchez-Laorden & Malin Pedersen & Simon J. Furney & Joel Rae & Kate Hogan & Sarah Ejiama & Maria Romina Girotti & Martin Cook & Nathalie Dhomen & Richard Marais, 2014. "Ultraviolet radiation accelerates BRAF-driven melanomagenesis by targeting TP53," Nature, Nature, vol. 511(7510), pages 478-482, July.
    • Handle: RePEc:nat:nature:v:511:y:2014:i:7510:d:10.1038_nature13298
    DOI: 10.1038/nature13298
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    Citations

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    Cited by:

    1. Marc A. Vittoria & Nathan Kingston & Kristyna Kotynkova & Eric Xia & Rui Hong & Lee Huang & Shayna McDonald & Andrew Tilston-Lunel & Revati Darp & Joshua D. Campbell & Deborah Lang & Xiaowei Xu & Crai, 2022. "Inactivation of the Hippo tumor suppressor pathway promotes melanoma," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    2. Jaskaren Kohli & Chen Ge & Eleni Fitsiou & Miriam Doepner & Simone M. Brandenburg & William J. Faller & Todd W. Ridky & Marco Demaria, 2022. "Targeting anti-apoptotic pathways eliminates senescent melanocytes and leads to nevi regression," Nature Communications, Nature, vol. 13(1), pages 1-12, December.

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