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CFIm25 links alternative polyadenylation to glioblastoma tumour suppression

Author

Listed:
  • Chioniso P. Masamha

    (The University of Texas Medical School at Houston)

  • Zheng Xia

    (Baylor College of Medicine)

  • Jingxuan Yang

    (The University of Texas Medical School at Houston)

  • Todd R. Albrecht

    (The University of Texas Medical School at Houston)

  • Min Li

    (The University of Texas Medical School at Houston)

  • Ann-Bin Shyu

    (The University of Texas Medical School at Houston)

  • Wei Li

    (Baylor College of Medicine)

  • Eric J. Wagner

    (The University of Texas Medical School at Houston)

Abstract

CFIm25 is identified as a factor that prevents messenger RNAs being shortened due to altered 3′ polyadenylation, which typically occurs when cells undergo high proliferation and correlates with increased tumorigenic activity in glioblastoma tumours.

Suggested Citation

  • Chioniso P. Masamha & Zheng Xia & Jingxuan Yang & Todd R. Albrecht & Min Li & Ann-Bin Shyu & Wei Li & Eric J. Wagner, 2014. "CFIm25 links alternative polyadenylation to glioblastoma tumour suppression," Nature, Nature, vol. 510(7505), pages 412-416, June.
    • Handle: RePEc:nat:nature:v:510:y:2014:i:7505:d:10.1038_nature13261
    DOI: 10.1038/nature13261
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    Citations

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    Cited by:

    1. Hui Chen & Zeyang Wang & Lihai Gong & Qixuan Wang & Wenyan Chen & Jia Wang & Xuelian Ma & Ruofan Ding & Xing Li & Xudong Zou & Mireya Plass & Cheng Lian & Ting Ni & Gong-Hong Wei & Wei Li & Lin Deng &, 2024. "A distinct class of pan-cancer susceptibility genes revealed by an alternative polyadenylation transcriptome-wide association study," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    2. Ya Cui & Frederick J. Arnold & Fanglue Peng & Dan Wang & Jason Sheng Li & Sebastian Michels & Eric J. Wagner & Albert R. Spada & Wei Li, 2023. "Alternative polyadenylation transcriptome-wide association study identifies APA-linked susceptibility genes in brain disorders," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    3. Seungjae Lee & Yen-Chung Chen & Austin E. Gillen & J. Matthew Taliaferro & Bart Deplancke & Hongjie Li & Eric C. Lai, 2022. "Diverse cell-specific patterns of alternative polyadenylation in Drosophila," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    4. Buki Kwon & Mervin M. Fansler & Neil D. Patel & Jihye Lee & Weirui Ma & Christine Mayr, 2022. "Enhancers regulate 3′ end processing activity to control expression of alternative 3′UTR isoforms," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    5. Zhiping Zhang & Bongmin Bae & Winston H. Cuddleston & Pedro Miura, 2023. "Coordination of alternative splicing and alternative polyadenylation revealed by targeted long read sequencing," Nature Communications, Nature, vol. 14(1), pages 1-14, December.

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