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Structure of the AcrAB–TolC multidrug efflux pump

Author

Listed:
  • Dijun Du

    (University of Cambridge, Tennis Court Road, Cambridge CB2 1GA, UK)

  • Zhao Wang

    (National Center for Macromolecular Imaging, Baylor College of Medicine)

  • Nathan R. James

    (University of Cambridge, Tennis Court Road, Cambridge CB2 1GA, UK)

  • Jarrod E. Voss

    (University of Cambridge, Tennis Court Road, Cambridge CB2 1GA, UK)

  • Ewa Klimont

    (University of Cambridge, Tennis Court Road, Cambridge CB2 1GA, UK)

  • Thelma Ohene-Agyei

    (Tennis Court Road, Cambridge CB2 1PD, UK)

  • Henrietta Venter

    (School of Pharmacy & Medical Sciences, Sansom Institute for Health Research, University of South Australia)

  • Wah Chiu

    (National Center for Macromolecular Imaging, Baylor College of Medicine)

  • Ben F. Luisi

    (University of Cambridge, Tennis Court Road, Cambridge CB2 1GA, UK)

Abstract

Many bacteria are able to survive in the presence of antibiotics in part because they possess pumps that can remove a broad range of small molecules; here, the structure of one such pump, AcrAB–TolC, is determined using X-ray crystallography and cryo-electron microscopy.

Suggested Citation

  • Dijun Du & Zhao Wang & Nathan R. James & Jarrod E. Voss & Ewa Klimont & Thelma Ohene-Agyei & Henrietta Venter & Wah Chiu & Ben F. Luisi, 2014. "Structure of the AcrAB–TolC multidrug efflux pump," Nature, Nature, vol. 509(7501), pages 512-515, May.
    • Handle: RePEc:nat:nature:v:509:y:2014:i:7501:d:10.1038_nature13205
    DOI: 10.1038/nature13205
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