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Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430

Author

Listed:
  • Travis K. Warren

    (Therapeutic Discovery Center, United States Army Medical Research Institute of Infectious Diseases (USAMRIID))

  • Jay Wells

    (Therapeutic Discovery Center, United States Army Medical Research Institute of Infectious Diseases (USAMRIID))

  • Rekha G. Panchal

    (Therapeutic Discovery Center, United States Army Medical Research Institute of Infectious Diseases (USAMRIID))

  • Kelly S. Stuthman

    (Therapeutic Discovery Center, United States Army Medical Research Institute of Infectious Diseases (USAMRIID))

  • Nicole L. Garza

    (Therapeutic Discovery Center, United States Army Medical Research Institute of Infectious Diseases (USAMRIID))

  • Sean A. Van Tongeren

    (Therapeutic Discovery Center, United States Army Medical Research Institute of Infectious Diseases (USAMRIID))

  • Lian Dong

    (Therapeutic Discovery Center, United States Army Medical Research Institute of Infectious Diseases (USAMRIID))

  • Cary J. Retterer

    (Therapeutic Discovery Center, United States Army Medical Research Institute of Infectious Diseases (USAMRIID))

  • Brett P. Eaton

    (Therapeutic Discovery Center, United States Army Medical Research Institute of Infectious Diseases (USAMRIID))

  • Gianluca Pegoraro

    (Therapeutic Discovery Center, United States Army Medical Research Institute of Infectious Diseases (USAMRIID))

  • Shelley Honnold

    (Therapeutic Discovery Center, United States Army Medical Research Institute of Infectious Diseases (USAMRIID))

  • Shanta Bantia

    (BioCryst Pharmaceuticals Inc.)

  • Pravin Kotian

    (BioCryst Pharmaceuticals Inc.)

  • Xilin Chen

    (BioCryst Pharmaceuticals Inc.)

  • Brian R. Taubenheim

    (BioCryst Pharmaceuticals Inc.
    Present address: Wilco Consulting, LLC, Durham, North Carolina 27712, USA.)

  • Lisa S. Welch

    (Therapeutic Discovery Center, United States Army Medical Research Institute of Infectious Diseases (USAMRIID))

  • Dena M. Minning

    (MedExpert Consulting, Inc.)

  • Yarlagadda S. Babu

    (BioCryst Pharmaceuticals Inc.)

  • William P. Sheridan

    (BioCryst Pharmaceuticals Inc.)

  • Sina Bavari

    (Therapeutic Discovery Center, United States Army Medical Research Institute of Infectious Diseases (USAMRIID))

Abstract

A broad-spectrum antiviral small molecule is reported to act as an inhibitor of viral polymerase activity and is shown to be effective in protecting non-human primates from lethal filovirus infection when administered after exposure.

Suggested Citation

  • Travis K. Warren & Jay Wells & Rekha G. Panchal & Kelly S. Stuthman & Nicole L. Garza & Sean A. Van Tongeren & Lian Dong & Cary J. Retterer & Brett P. Eaton & Gianluca Pegoraro & Shelley Honnold & Sha, 2014. "Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430," Nature, Nature, vol. 508(7496), pages 402-405, April.
    • Handle: RePEc:nat:nature:v:508:y:2014:i:7496:d:10.1038_nature13027
    DOI: 10.1038/nature13027
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