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Polarized release of T-cell-receptor-enriched microvesicles at the immunological synapse

Author

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  • Kaushik Choudhuri

    (Program in Molecular Pathogenesis, Helen L. and Martin S. Kimmel Center for Biology and Medicine of the Skirball Institute of Biomolecular Medicine, 540 First Avenue, New York, New York 10016, USA)

  • Jaime Llodrá

    (Program in Structural Biology, Helen L. and Martin S. Kimmel Center for Biology and Medicine of the Skirball Institute of Biomolecular Medicine, 540 First Avenue, New York, New York 10016, USA)

  • Eric W. Roth

    (Northwestern University Atomic and Nanoscale Characterization Experimental Center, Northwestern University, 2220 Campus Drive)

  • Jones Tsai

    (Columbia University, 500 W 120th Street, New York, New York 10027, USA)

  • Susana Gordo

    (Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, Massachusetts 02215, USA
    Program in Immunology, Harvard Medical School)

  • Kai W. Wucherpfennig

    (Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, Massachusetts 02215, USA
    Program in Immunology, Harvard Medical School)

  • Lance C. Kam

    (Columbia University, 500 W 120th Street, New York, New York 10027, USA)

  • David L. Stokes

    (Program in Structural Biology, Helen L. and Martin S. Kimmel Center for Biology and Medicine of the Skirball Institute of Biomolecular Medicine, 540 First Avenue, New York, New York 10016, USA
    New York Structural Biology Center, 89 Convent Avenue, New York, New York 10027, USA)

  • Michael L. Dustin

    (New York University School of Medicine, 540 First Avenue, New York, New York 10016, USA
    Kennedy Institute of Rheumatology, Rheumatology and Musculoskeletal Sciences, The University of Oxford, Roosevelt Drive, Headington, Oxford OX3 7FY, UK)

Abstract

Here it is shown that T-cell receptors accumulate at the immunological synapse after stimulation with cognate antigen and are released in extracellular microvesicles by an ESCRT-dependent mechanism, the microvesicles deliver transcellular signals from CD4 T cells to antigen-presenting B cells and can induce B-cell signalling.

Suggested Citation

  • Kaushik Choudhuri & Jaime Llodrá & Eric W. Roth & Jones Tsai & Susana Gordo & Kai W. Wucherpfennig & Lance C. Kam & David L. Stokes & Michael L. Dustin, 2014. "Polarized release of T-cell-receptor-enriched microvesicles at the immunological synapse," Nature, Nature, vol. 507(7490), pages 118-123, March.
    • Handle: RePEc:nat:nature:v:507:y:2014:i:7490:d:10.1038_nature12951
    DOI: 10.1038/nature12951
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    Cited by:

    1. Jeong-Su Park & Jun-Hyeong Kim & Won-Chang Soh & Na-Young Kim & Kyung-Sik Lee & Chang-Hyun Kim & Ik-Joo Chung & Sunjae Lee & Hye-Ran Kim & Chang-Duk Jun, 2023. "Trogocytic molting of T cell microvilli upregulates T cell receptor surface expression and promotes clonal expansion," Nature Communications, Nature, vol. 14(1), pages 1-22, December.
    2. Dingxi Zhou & Mariana Borsa & Daniel J. Puleston & Susanne Zellner & Jesusa Capera & Sharon Sanderson & Martina Schifferer & Svenja S. Hester & Xin Ge & Roman Fischer & Luke Jostins & Christian Behren, 2022. "Mapping autophagosome contents identifies interleukin-7 receptor-α as a key cargo modulating CD4+ T cell proliferation," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    3. Christopher Szeto & Pirooz Zareie & Rushika C. Wirasinha & Justin B. Zhang & Andrea T. Nguyen & Alan Riboldi-Tunnicliffe & Nicole L. Gruta & Stephanie Gras & Stephen R. Daley, 2022. "Covalent TCR-peptide-MHC interactions induce T cell activation and redirect T cell fate in the thymus," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    4. Sarah Renaud & Anthony Lefebvre & Olivier Moralès & Nadira Delhem, 2019. "Mini Review - Exosomes from Discovery to Isolation," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 15(2), pages 11286-11293, February.
    5. Pablo F. Céspedes & Ashwin Jainarayanan & Lola Fernández-Messina & Salvatore Valvo & David G. Saliba & Elke Kurz & Audun Kvalvaag & Lina Chen & Charity Ganskow & Huw Colin-York & Marco Fritzsche & Yan, 2022. "T-cell trans-synaptic vesicles are distinct and carry greater effector content than constitutive extracellular vesicles," Nature Communications, Nature, vol. 13(1), pages 1-18, December.

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