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Stressful genetics in Crohn's disease

Author

Listed:
  • Arthur Kaser

    (Addenbrooke's Hospital, University of Cambridge, Cambridge CB2 0QQ, UK.)

  • Richard S. Blumberg

    (Hepatology and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.)

Abstract

A common variant of the autophagy protein ATG16L1 is a risk factor for Crohn's disease. But the genetic alteration is revealed only when the protein is cleaved by the enzyme caspase 3 during cellular stress. See Article p.456

Suggested Citation

  • Arthur Kaser & Richard S. Blumberg, 2014. "Stressful genetics in Crohn's disease," Nature, Nature, vol. 506(7489), pages 441-442, February.
    • Handle: RePEc:nat:nature:v:506:y:2014:i:7489:d:10.1038_nature13060
    DOI: 10.1038/nature13060
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