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Landscape of genomic alterations in cervical carcinomas

Author

Listed:
  • Akinyemi I. Ojesina

    (Dana-Farber Cancer Institute
    The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University)

  • Lee Lichtenstein

    (The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University)

  • Samuel S. Freeman

    (The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University)

  • Chandra Sekhar Pedamallu

    (Dana-Farber Cancer Institute
    The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University)

  • Ivan Imaz-Rosshandler

    (Instituto Nacional de Medicina Genomica, Mexico City 14610, Mexico)

  • Trevor J. Pugh

    (Dana-Farber Cancer Institute
    The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University)

  • Andrew D. Cherniack

    (The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University)

  • Lauren Ambrogio

    (The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University)

  • Kristian Cibulskis

    (The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University)

  • Bjørn Bertelsen

    (Haukeland University Hospital, N5021 Bergen, Norway)

  • Sandra Romero-Cordoba

    (Instituto Nacional de Medicina Genomica, Mexico City 14610, Mexico)

  • Victor Treviño

    (Tecnológico de Monterrey, Monterrey 64849, Mexico)

  • Karla Vazquez-Santillan

    (Instituto Nacional de Medicina Genomica, Mexico City 14610, Mexico)

  • Alberto Salido Guadarrama

    (Instituto Nacional de Medicina Genomica, Mexico City 14610, Mexico)

  • Alexi A. Wright

    (Dana-Farber Cancer Institute
    Brigham and Women’s Hospital)

  • Mara W. Rosenberg

    (The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University)

  • Fujiko Duke

    (Dana-Farber Cancer Institute)

  • Bethany Kaplan

    (Dana-Farber Cancer Institute
    The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University)

  • Rui Wang

    (Dana-Farber Cancer Institute
    Fudan University Shanghai Cancer Center)

  • Elizabeth Nickerson

    (The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University)

  • Heather M. Walline

    (Cancer Biology Program, Program in the Biomedical Sciences, Rackham Graduate School, University of Michigan)

  • Michael S. Lawrence

    (The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University)

  • Chip Stewart

    (The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University)

  • Scott L. Carter

    (The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University)

  • Aaron McKenna

    (The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University)

  • Iram P. Rodriguez-Sanchez

    (Facultad de Medicina y Hospital Universitario ‘Dr. José Eluterio González’ de la Universidad Autónoma de Nuevo León, Monterrey, Nuevo León 64460, México)

  • Magali Espinosa-Castilla

    (Instituto Nacional de Medicina Genomica, Mexico City 14610, Mexico)

  • Kathrine Woie

    (Haukeland University Hospital, N5021 Bergen, Norway)

  • Line Bjorge

    (Haukeland University Hospital, N5021 Bergen, Norway
    Centre for Cancer Biomarkers, University of Bergen, N5020 Bergen, Norway)

  • Elisabeth Wik

    (Haukeland University Hospital, N5021 Bergen, Norway
    Centre for Cancer Biomarkers, University of Bergen, N5020 Bergen, Norway)

  • Mari K. Halle

    (Haukeland University Hospital, N5021 Bergen, Norway
    Centre for Cancer Biomarkers, University of Bergen, N5020 Bergen, Norway)

  • Erling A. Hoivik

    (Haukeland University Hospital, N5021 Bergen, Norway
    Centre for Cancer Biomarkers, University of Bergen, N5020 Bergen, Norway)

  • Camilla Krakstad

    (Haukeland University Hospital, N5021 Bergen, Norway
    Centre for Cancer Biomarkers, University of Bergen, N5020 Bergen, Norway)

  • Nayeli Belem Gabiño

    (Instituto Nacional de Medicina Genomica, Mexico City 14610, Mexico)

  • Gabriela Sofia Gómez-Macías

    (Facultad de Medicina y Hospital Universitario ‘Dr. José Eluterio González’ de la Universidad Autónoma de Nuevo León, Monterrey, Nuevo León 64460, México)

  • Lezmes D. Valdez-Chapa

    (Facultad de Medicina y Hospital Universitario ‘Dr. José Eluterio González’ de la Universidad Autónoma de Nuevo León, Monterrey, Nuevo León 64460, México)

  • María Lourdes Garza-Rodríguez

    (Facultad de Medicina y Hospital Universitario ‘Dr. José Eluterio González’ de la Universidad Autónoma de Nuevo León, Monterrey, Nuevo León 64460, México)

  • German Maytorena

    (Instituto Mexicano del Seguro Social, Mexico City 06720, Mexico)

  • Jorge Vazquez

    (Instituto Mexicano del Seguro Social, Mexico City 06720, Mexico)

  • Carlos Rodea

    (Instituto Mexicano del Seguro Social, Mexico City 06720, Mexico)

  • Adrian Cravioto

    (Instituto Mexicano del Seguro Social, Mexico City 06720, Mexico)

  • Maria L. Cortes

    (The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University)

  • Heidi Greulich

    (Dana-Farber Cancer Institute
    The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University
    Brigham and Women’s Hospital)

  • Christopher P. Crum

    (Brigham and Women’s Hospital)

  • Donna S. Neuberg

    (Dana-Farber Cancer Institute)

  • Alfredo Hidalgo-Miranda

    (Instituto Nacional de Medicina Genomica, Mexico City 14610, Mexico)

  • Claudia Rangel Escareno

    (Instituto Nacional de Medicina Genomica, Mexico City 14610, Mexico
    Claremont Graduate University)

  • Lars A. Akslen

    (Haukeland University Hospital, N5021 Bergen, Norway
    Centre for Cancer Biomarkers, University of Bergen, N5020 Bergen, Norway)

  • Thomas E. Carey

    (University of Michigan Comprehensive Cancer Center)

  • Olav K. Vintermyr

    (Haukeland University Hospital, N5021 Bergen, Norway
    Centre for Cancer Biomarkers, University of Bergen, N5020 Bergen, Norway)

  • Stacey B. Gabriel

    (The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University)

  • Hugo A. Barrera-Saldaña

    (Facultad de Medicina y Hospital Universitario ‘Dr. José Eluterio González’ de la Universidad Autónoma de Nuevo León, Monterrey, Nuevo León 64460, México)

  • Jorge Melendez-Zajgla

    (Instituto Nacional de Medicina Genomica, Mexico City 14610, Mexico)

  • Gad Getz

    (The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University
    Massachusetts General Hospital and Harvard Medical School)

  • Helga B. Salvesen

    (Haukeland University Hospital, N5021 Bergen, Norway
    Centre for Cancer Biomarkers, University of Bergen, N5020 Bergen, Norway)

  • Matthew Meyerson

    (Dana-Farber Cancer Institute
    The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University
    Brigham and Women’s Hospital)

Abstract

Whole-exome sequencing and analysis of 115 cervical carcinoma–normal paired samples, in addition to transcriptome and whole-genome sequencing for a subset of these tumours, reveal novel genes mutated at significant levels within this cohort and provide evidence that HPV integration is a common mechanism for target gene overexpression; results also compare mutational landscapes between squamous cell carcinomas and adenocarcinomas.

Suggested Citation

  • Akinyemi I. Ojesina & Lee Lichtenstein & Samuel S. Freeman & Chandra Sekhar Pedamallu & Ivan Imaz-Rosshandler & Trevor J. Pugh & Andrew D. Cherniack & Lauren Ambrogio & Kristian Cibulskis & Bjørn Bert, 2014. "Landscape of genomic alterations in cervical carcinomas," Nature, Nature, vol. 506(7488), pages 371-375, February.
    • Handle: RePEc:nat:nature:v:506:y:2014:i:7488:d:10.1038_nature12881
    DOI: 10.1038/nature12881
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    Citations

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    Cited by:

    1. Liyuan Zhou & Qiongzi Qiu & Qing Zhou & Jianwei Li & Mengqian Yu & Kezhen Li & Lingling Xu & Xiaohui Ke & Haiming Xu & Bingjian Lu & Hui Wang & Weiguo Lu & Pengyuan Liu & Yan Lu, 2022. "Long-read sequencing unveils high-resolution HPV integration and its oncogenic progression in cervical cancer," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    2. Ankur Chakravarthy & Ian Reddin & Stephen Henderson & Cindy Dong & Nerissa Kirkwood & Maxmilan Jeyakumar & Daniela Rothschild Rodriguez & Natalia Gonzalez Martinez & Jacqueline McDermott & Xiaoping Su, 2022. "Integrated analysis of cervical squamous cell carcinoma cohorts from three continents reveals conserved subtypes of prognostic significance," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    3. Xiaoli Wang & Wenlong Jia & Mengyao Wang & Jihong Liu & Xianrong Zhou & Zhiqing Liang & Qinghua Zhang & Sixiang Long & Suolang Quzhen & Xiangchun Li & Qiang Tian & Xiong Li & Haiying Sun & Caili Zhao , 2022. "Human papillomavirus integration perspective in small cell cervical carcinoma," Nature Communications, Nature, vol. 13(1), pages 1-10, December.

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