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Role of Tet1 in erasure of genomic imprinting

Author

Listed:
  • Shinpei Yamaguchi

    (Howard Hughes Medical Institute, Boston Children's Hospital
    Program in Cellular and Molecular Medicine, Boston Children's Hospital
    Boston Children’s Hospital)

  • Li Shen

    (Howard Hughes Medical Institute, Boston Children's Hospital)

  • Yuting Liu

    (Howard Hughes Medical Institute, Boston Children's Hospital
    Program in Cellular and Molecular Medicine, Boston Children's Hospital
    Boston Children’s Hospital)

  • Damian Sendler

    (Howard Hughes Medical Institute, Boston Children's Hospital)

  • Yi Zhang

    (Howard Hughes Medical Institute, Boston Children's Hospital
    Program in Cellular and Molecular Medicine, Boston Children's Hospital
    Boston Children’s Hospital
    Harvard Medical School)

Abstract

This study establishes an important role for the enzyme Tet1 in erasing genomic imprinting in vivo — mice with a knockout of paternal Tet1 give rise to progeny with imprinting defects and associated growth and development defects, which leads to early embryonic lethality; furthermore, analysis of the DNA methylation dynamics in reprogramming primordial germ cells (PGCs) suggests that Tet1 is required at a late stage of the reprogramming process, in the second wave of DNA demethylation in PGCs.

Suggested Citation

  • Shinpei Yamaguchi & Li Shen & Yuting Liu & Damian Sendler & Yi Zhang, 2013. "Role of Tet1 in erasure of genomic imprinting," Nature, Nature, vol. 504(7480), pages 460-464, December.
  • Handle: RePEc:nat:nature:v:504:y:2013:i:7480:d:10.1038_nature12805
    DOI: 10.1038/nature12805
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