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Themis sets the signal threshold for positive and negative selection in T-cell development

Author

Listed:
  • Guo Fu

    (The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA)

  • Javier Casas

    (The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Yong Loo Lin School of Medicine and Immunology Programme, National University of Singapore, 5 Science Drive 2, Singapore 117545)

  • Stephanie Rigaud

    (The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA)

  • Vasily Rybakin

    (The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Yong Loo Lin School of Medicine and Immunology Programme, National University of Singapore, 5 Science Drive 2, Singapore 117545)

  • Florence Lambolez

    (Developmental Immunology, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, California 92037, USA)

  • Joanna Brzostek

    (The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Yong Loo Lin School of Medicine and Immunology Programme, National University of Singapore, 5 Science Drive 2, Singapore 117545)

  • John A. H. Hoerter

    (The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA)

  • Wolfgang Paster

    (Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK)

  • Oreste Acuto

    (Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK)

  • Hilde Cheroutre

    (Developmental Immunology, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, California 92037, USA)

  • Karsten Sauer

    (The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA)

  • Nicholas R. J. Gascoigne

    (The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Yong Loo Lin School of Medicine and Immunology Programme, National University of Singapore, 5 Science Drive 2, Singapore 117545)

Abstract

This work shows that the Themis protein has a critical role in positive and negative thymocyte selection by dampening responses to low-affinity ligands but without affecting responses to high-affinity ligands, thus enabling positive selection of weakly self-reactive thymocytes.

Suggested Citation

  • Guo Fu & Javier Casas & Stephanie Rigaud & Vasily Rybakin & Florence Lambolez & Joanna Brzostek & John A. H. Hoerter & Wolfgang Paster & Oreste Acuto & Hilde Cheroutre & Karsten Sauer & Nicholas R. J., 2013. "Themis sets the signal threshold for positive and negative selection in T-cell development," Nature, Nature, vol. 504(7480), pages 441-445, December.
    • Handle: RePEc:nat:nature:v:504:y:2013:i:7480:d:10.1038_nature12718
    DOI: 10.1038/nature12718
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