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Primary cilia are specialized calcium signalling organelles

Author

Listed:
  • Markus Delling

    (Howard Hughes Medical Institute, Boston Children’s Hospital, 320 Longwood Avenue, Boston, Massachusetts 02115, USA)

  • Paul G. DeCaen

    (Howard Hughes Medical Institute, Boston Children’s Hospital, 320 Longwood Avenue, Boston, Massachusetts 02115, USA)

  • Julia F. Doerner

    (Howard Hughes Medical Institute, Boston Children’s Hospital, 320 Longwood Avenue, Boston, Massachusetts 02115, USA)

  • Sebastien Febvay

    (Howard Hughes Medical Institute, Boston Children’s Hospital, 320 Longwood Avenue, Boston, Massachusetts 02115, USA)

  • David E. Clapham

    (Howard Hughes Medical Institute, Boston Children’s Hospital, 320 Longwood Avenue, Boston, Massachusetts 02115, USA
    Harvard Medical School)

Abstract

Primary cilia are known as specialized calcium signalling compartments on the cell surface, but the ionic permeability and other physiological properties of these protrusions are unknown—this is one of two studies identifying the ion channels that densely populate primary cilia, with direct measurements revealing cilia as a unique, functionally independent calcium signalling compartment that modulates hedgehog signalling pathways.

Suggested Citation

  • Markus Delling & Paul G. DeCaen & Julia F. Doerner & Sebastien Febvay & David E. Clapham, 2013. "Primary cilia are specialized calcium signalling organelles," Nature, Nature, vol. 504(7479), pages 311-314, December.
    • Handle: RePEc:nat:nature:v:504:y:2013:i:7479:d:10.1038_nature12833
    DOI: 10.1038/nature12833
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    Cited by:

    1. Adelaida R. Palla & Keren I. Hilgendorf & Ann V. Yang & Jaclyn P. Kerr & Aaron C. Hinken & Janos Demeter & Peggy Kraft & Nancie A. Mooney & Nora Yucel & David M. Burns & Yu Xin Wang & Peter K. Jackson, 2022. "Primary cilia on muscle stem cells are critical to maintain regenerative capacity and are lost during aging," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    2. Sienna R. Li & Ramila E. Gulieva & Louisa Helms & Nelly M. Cruz & Thomas Vincent & Hongxia Fu & Jonathan Himmelfarb & Benjamin S. Freedman, 2022. "Glucose absorption drives cystogenesis in a human organoid-on-chip model of polycystic kidney disease," Nature Communications, Nature, vol. 13(1), pages 1-12, December.

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