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Structural basis for action by diverse antidepressants on biogenic amine transporters

Author

Listed:
  • Hui Wang

    (Vollum Institute, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA)

  • April Goehring

    (Vollum Institute, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA)

  • Kevin H. Wang

    (Vollum Institute, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA)

  • Aravind Penmatsa

    (Vollum Institute, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA)

  • Ryan Ressler

    (Vollum Institute, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA)

  • Eric Gouaux

    (Vollum Institute, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA
    Howard Hughes Medical Institute, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA)

Abstract

LeuT, a bacterial homologue of eukaryotic biogenic amine transporters (BATs), is engineered to harbour human BAT-like pharmacology by the mutation of key residues around the primary binding pocket; this mutant is able to bind several classes of antidepressant drug with high affinity, helping to define their common mechanisms of action.

Suggested Citation

  • Hui Wang & April Goehring & Kevin H. Wang & Aravind Penmatsa & Ryan Ressler & Eric Gouaux, 2013. "Structural basis for action by diverse antidepressants on biogenic amine transporters," Nature, Nature, vol. 503(7474), pages 141-145, November.
    • Handle: RePEc:nat:nature:v:503:y:2013:i:7474:d:10.1038_nature12648
    DOI: 10.1038/nature12648
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