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Chromatin proteins and modifications as drug targets

Author

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  • Kristian Helin

    (Biotech Research and Innovation Centre, University of Copenhagen
    Centre for Epigenetics, University of Copenhagen
    The Danish Stem Cell Center, University of Copenhagen)

  • Dashyant Dhanak

    (Janssen Research & Development)

Abstract

A plethora of groundbreaking studies have demonstrated the importance of chromatin-associated proteins and post-translational modifications of histones, proteins and DNA (so-called epigenetic modifications) for transcriptional control and normal development. Disruption of epigenetic control is a frequent event in disease, and the first epigenetic-based therapies for cancer treatment have been approved. A generation of new classes of potent and specific inhibitors for several chromatin-associated proteins have shown promise in preclinical trials. Although the biology of epigenetic regulation is complex, new inhibitors such as these will hopefully be of clinical use in the coming years.

Suggested Citation

  • Kristian Helin & Dashyant Dhanak, 2013. "Chromatin proteins and modifications as drug targets," Nature, Nature, vol. 502(7472), pages 480-488, October.
  • Handle: RePEc:nat:nature:v:502:y:2013:i:7472:d:10.1038_nature12751
    DOI: 10.1038/nature12751
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