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Human MX2 is an interferon-induced post-entry inhibitor of HIV-1 infection

Author

Listed:
  • Caroline Goujon

    (King’s College London, London SE1 9RT, UK)

  • Olivier Moncorgé

    (Section of Virology, Imperial College London, London W2 1PG, UK)

  • Hélène Bauby

    (King’s College London, London SE1 9RT, UK)

  • Tomas Doyle

    (King’s College London, London SE1 9RT, UK)

  • Christopher C. Ward

    (King’s College London, London SE1 9RT, UK)

  • Torsten Schaller

    (King’s College London, London SE1 9RT, UK)

  • Stéphane Hué

    (Centre for Medical Molecular Virology, University College London, London WC1 6RT, UK)

  • Wendy S. Barclay

    (Section of Virology, Imperial College London, London W2 1PG, UK)

  • Reiner Schulz

    (King’s College London, London SE1 9RT, UK)

  • Michael H. Malim

    (King’s College London, London SE1 9RT, UK)

Abstract

Here, a protein known as MX2 is shown to be a major effector of interferon-α-mediated resistance to HIV-1 infection: susceptibility of the HIV-1 virus to inhibition by MX2 is dictated by the Capsid region of the viral Gag protein, and inhibition occurs at a late post-entry step of infection.

Suggested Citation

  • Caroline Goujon & Olivier Moncorgé & Hélène Bauby & Tomas Doyle & Christopher C. Ward & Torsten Schaller & Stéphane Hué & Wendy S. Barclay & Reiner Schulz & Michael H. Malim, 2013. "Human MX2 is an interferon-induced post-entry inhibitor of HIV-1 infection," Nature, Nature, vol. 502(7472), pages 559-562, October.
    • Handle: RePEc:nat:nature:v:502:y:2013:i:7472:d:10.1038_nature12542
    DOI: 10.1038/nature12542
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