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The genesis and source of the H7N9 influenza viruses causing human infections in China

Author

Listed:
  • Tommy Tsan-Yuk Lam

    (Joint Influenza Research Centre (SUMC/HKU), Shantou University Medical College
    State Key Laboratory of Emerging Infectious Diseases (HKU-Shenzhen Branch), Shenzhen Third People’s Hospital
    State Key Laboratory of Emerging Infectious Diseases/Centre of Influenza Research, School of Public Health, The University of Hong Kong)

  • Jia Wang

    (Joint Influenza Research Centre (SUMC/HKU), Shantou University Medical College
    State Key Laboratory of Emerging Infectious Diseases/Centre of Influenza Research, School of Public Health, The University of Hong Kong)

  • Yongyi Shen

    (Joint Influenza Research Centre (SUMC/HKU), Shantou University Medical College
    State Key Laboratory of Emerging Infectious Diseases/Centre of Influenza Research, School of Public Health, The University of Hong Kong
    State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University)

  • Boping Zhou

    (State Key Laboratory of Emerging Infectious Diseases (HKU-Shenzhen Branch), Shenzhen Third People’s Hospital)

  • Lian Duan

    (State Key Laboratory of Emerging Infectious Diseases (HKU-Shenzhen Branch), Shenzhen Third People’s Hospital
    State Key Laboratory of Emerging Infectious Diseases/Centre of Influenza Research, School of Public Health, The University of Hong Kong)

  • Chung-Lam Cheung

    (State Key Laboratory of Emerging Infectious Diseases/Centre of Influenza Research, School of Public Health, The University of Hong Kong)

  • Chi Ma

    (Joint Influenza Research Centre (SUMC/HKU), Shantou University Medical College
    State Key Laboratory of Emerging Infectious Diseases/Centre of Influenza Research, School of Public Health, The University of Hong Kong)

  • Samantha J. Lycett

    (Institute of Evolutionary Biology, University of Edinburgh, Edinburgh EH9 3JT, UK)

  • Connie Yin-Hung Leung

    (State Key Laboratory of Emerging Infectious Diseases/Centre of Influenza Research, School of Public Health, The University of Hong Kong)

  • Xinchun Chen

    (State Key Laboratory of Emerging Infectious Diseases (HKU-Shenzhen Branch), Shenzhen Third People’s Hospital)

  • Lifeng Li

    (Joint Influenza Research Centre (SUMC/HKU), Shantou University Medical College
    State Key Laboratory of Emerging Infectious Diseases (HKU-Shenzhen Branch), Shenzhen Third People’s Hospital
    State Key Laboratory of Emerging Infectious Diseases/Centre of Influenza Research, School of Public Health, The University of Hong Kong)

  • Wenshan Hong

    (Joint Influenza Research Centre (SUMC/HKU), Shantou University Medical College)

  • Yujuan Chai

    (State Key Laboratory of Emerging Infectious Diseases (HKU-Shenzhen Branch), Shenzhen Third People’s Hospital
    State Key Laboratory of Emerging Infectious Diseases/Centre of Influenza Research, School of Public Health, The University of Hong Kong)

  • Linlin Zhou

    (State Key Laboratory of Emerging Infectious Diseases/Centre of Influenza Research, School of Public Health, The University of Hong Kong)

  • Huyi Liang

    (Joint Influenza Research Centre (SUMC/HKU), Shantou University Medical College
    State Key Laboratory of Emerging Infectious Diseases (HKU-Shenzhen Branch), Shenzhen Third People’s Hospital
    State Key Laboratory of Emerging Infectious Diseases/Centre of Influenza Research, School of Public Health, The University of Hong Kong)

  • Zhihua Ou

    (Joint Influenza Research Centre (SUMC/HKU), Shantou University Medical College
    State Key Laboratory of Emerging Infectious Diseases (HKU-Shenzhen Branch), Shenzhen Third People’s Hospital
    State Key Laboratory of Emerging Infectious Diseases/Centre of Influenza Research, School of Public Health, The University of Hong Kong)

  • Yongmei Liu

    (Joint Influenza Research Centre (SUMC/HKU), Shantou University Medical College
    State Key Laboratory of Emerging Infectious Diseases/Centre of Influenza Research, School of Public Health, The University of Hong Kong)

  • Amber Farooqui

    (Joint Vaccine Research Centre (SUMC/UHN), Shantou University Medical College, Shantou 515041, China)

  • David J. Kelvin

    (Joint Vaccine Research Centre (SUMC/UHN), Shantou University Medical College, Shantou 515041, China)

  • Leo L. M. Poon

    (State Key Laboratory of Emerging Infectious Diseases (HKU-Shenzhen Branch), Shenzhen Third People’s Hospital
    State Key Laboratory of Emerging Infectious Diseases/Centre of Influenza Research, School of Public Health, The University of Hong Kong)

  • David K. Smith

    (Joint Influenza Research Centre (SUMC/HKU), Shantou University Medical College
    State Key Laboratory of Emerging Infectious Diseases/Centre of Influenza Research, School of Public Health, The University of Hong Kong)

  • Oliver G. Pybus

    (University of Oxford, Oxford OX1 3PS, UK
    Metabiota)

  • Gabriel M. Leung

    (Joint Influenza Research Centre (SUMC/HKU), Shantou University Medical College
    State Key Laboratory of Emerging Infectious Diseases/Centre of Influenza Research, School of Public Health, The University of Hong Kong)

  • Yuelong Shu

    (National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health and Family Planning Commission)

  • Robert G. Webster

    (St Jude Children’s Research Hospital)

  • Richard J. Webby

    (St Jude Children’s Research Hospital)

  • Joseph S. M. Peiris

    (State Key Laboratory of Emerging Infectious Diseases (HKU-Shenzhen Branch), Shenzhen Third People’s Hospital
    State Key Laboratory of Emerging Infectious Diseases/Centre of Influenza Research, School of Public Health, The University of Hong Kong)

  • Andrew Rambaut

    (Institute of Evolutionary Biology, University of Edinburgh, Edinburgh EH9 3JT, UK
    Fogarty International Center, National Institutes of Health)

  • Huachen Zhu

    (Joint Influenza Research Centre (SUMC/HKU), Shantou University Medical College
    State Key Laboratory of Emerging Infectious Diseases (HKU-Shenzhen Branch), Shenzhen Third People’s Hospital
    State Key Laboratory of Emerging Infectious Diseases/Centre of Influenza Research, School of Public Health, The University of Hong Kong)

  • Yi Guan

    (Joint Influenza Research Centre (SUMC/HKU), Shantou University Medical College
    State Key Laboratory of Emerging Infectious Diseases (HKU-Shenzhen Branch), Shenzhen Third People’s Hospital
    State Key Laboratory of Emerging Infectious Diseases/Centre of Influenza Research, School of Public Health, The University of Hong Kong)

Abstract

Evolutionary analyses show that H7 influenza viruses probably transferred from ducks to chickens in China on at least two independent occasions, and that reassortment with H9N2 viruses generated the H7N9 outbreak lineage that recently emerged in humans in China, and a related previously unrecognized H7N7 lineage; these H7N7 viruses are shown to have the ability to infect ferrets, and the current pandemic threat could extend beyond H7N9 viruses.

Suggested Citation

  • Tommy Tsan-Yuk Lam & Jia Wang & Yongyi Shen & Boping Zhou & Lian Duan & Chung-Lam Cheung & Chi Ma & Samantha J. Lycett & Connie Yin-Hung Leung & Xinchun Chen & Lifeng Li & Wenshan Hong & Yujuan Chai &, 2013. "The genesis and source of the H7N9 influenza viruses causing human infections in China," Nature, Nature, vol. 502(7470), pages 241-244, October.
    • Handle: RePEc:nat:nature:v:502:y:2013:i:7470:d:10.1038_nature12515
    DOI: 10.1038/nature12515
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